Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective
| Autor: | M Hasan Toper, Sulen Sarioglu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Adenoma business.industry Adenoid cystic carcinoma Molecular pathology medicine.disease Pathology and Forensic Medicine Pleomorphic adenoma 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Carcinoma ex pleomorphic adenoma Mucoepidermoid carcinoma 030220 oncology & carcinogenesis Clear cell carcinoma medicine Carcinoma Anatomy business |
| Zdroj: | Advances in Anatomic Pathology. 28:81-93 |
| ISSN: | 1072-4109 |
| DOI: | 10.1097/pap.0000000000000291 |
| Popis: | Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In recent years, there has been considerable progress in efforts to reveal the molecular landscape of these tumors, although it is still limited and appears to be only the tip of the iceberg. Genomic aberrations, especially specific chromosomal rearrangements including CRTC1-MAML2 and CRTC3-MAML2 in mucoepidermoid carcinoma, MYB-NFIB and MYBL1-NFIB fusions in adenoid cystic carcinoma, PLAG1 and HMGA2 alterations in pleomorphic adenoma and carcinoma ex pleomorphic adenoma, ETV6-NTRK3 and ETV6-RET in secretory carcinoma, EWSR1-ATF1 and EWSR1-CREM in clear cell carcinoma, provide new insights into the molecular pathogenesis of various salivary gland neoplasms and help to better classify them. These genetic aberrations primarily serve as diagnostic tools in salivary gland tumor diagnosis; however, some also have promise as prognostic or predictive biomarkers. This review summarizes the latest developments in molecular pathology of salivary gland tumors with a focus on distinctive molecular characteristics. |
| Databáze: | OpenAIRE |
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