Baicalin attenuates Alzheimer-like pathological changes and memory deficits induced by amyloid β1–42 protein
| Autor: | Xiao-Hong Li, Chong Chen, Peilong Gao, Jianwei Li, Yue Tu, Sai Zhang, Hai-Qian Liang, Ming-liang Zhao |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cell Morris water navigation task Pharmacology Biochemistry Neuroprotection Mice Cellular and Molecular Neuroscience chemistry.chemical_compound Western blot Alzheimer Disease Animals Medicine Hippocampus (mythology) Maze Learning Neuroinflammation Flavonoids Memory Disorders Mice Inbred ICR Amyloid beta-Peptides medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal Macrophage Activation Immunohistochemistry Peptide Fragments medicine.anatomical_structure chemistry Immunology Cytokines Neurology (clinical) Cognition Disorders business Neuroglia Baicalin |
| Zdroj: | Metabolic Brain Disease. 30:537-544 |
| ISSN: | 1573-7365 0885-7490 |
| Popis: | Baicalin is one bioactive flavone with anti-inflammatory and neuroprotective activities. The neuroprotective effects of baicalin on pathological changes and behavioral deficits were explored in a mouse model of amyloid β (Aβ)(1-42) protein-induced Alzheimer's disease (AD). Mice received a bilateral injection of Aβ(1-42) protein into the hippocampus, then they were treated with baicalin (30, 50 and 100 mg/kg body weight, orally) or Tween 80. The therapeutic effects of baicalin were monitored by Morris water maze trial and probe test. Then mice were sacrificed for immunohistochemistry and western blot analysis. After a relatively short-term treatment of 14 days, 100 mg/kg of baicalin significantly ameliorated memory impairment in the Morris water maze test and probe test, and also attenuated glial cell activations and increase of TNF-α and IL-6 expressions induced by Aβ(1-42) protein. These results suggest that baicalin ameliorated Aβ(1-42) protein-related pathology and cognitive dysfunction via its anti-neuroinflammatory activity, and may be a potential candidate for the treatment of AD. |
| Databáze: | OpenAIRE |
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