Cardiorespiratory responses, nitric oxide production and inflammatory factors in patients with myocardial infarction after rehabilitation
| Autor: | Sonia H. Torres, Noelina Hernández, José V. Subiela, Juan B. De Sanctis |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Physiology Clinical Biochemistry CD40 Ligand Myocardial Infarction 030204 cardiovascular system & hematology Nitric Oxide Biochemistry Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Transforming Growth Factor beta Internal medicine medicine Humans Myocardial infarction Nitrites Inflammation Muscle biopsy Cardiac Rehabilitation Nitrates medicine.diagnostic_test business.industry Interleukin-6 Tumor Necrosis Factor-alpha Nitrotyrosine Skeletal muscle Interleukin Cardiorespiratory fitness Middle Aged medicine.disease medicine.anatomical_structure chemistry Cardiology Tyrosine Tumor necrosis factor alpha Nitric Oxide Synthase business 030217 neurology & neurosurgery |
| Zdroj: | Nitric oxide : biology and chemistry. 76 |
| ISSN: | 1089-8611 |
| Popis: | There is evidence that myocardial infarction (MI) patients have an inflammatory process that includes skeletal muscles, and exercise has been reported to reduce some inflammatory markers. The aim of this work was to study NO and some inflammatory markers in quadriceps muscle of MI patients before and after cardiac rehabilitation. Muscle biopsy was obtained in 17 MI patients before and after CR and only once in 11 healthy subjects. Several cardiorespiratory and metabolic parameters were evaluated and skeletal muscle levels of nitric oxide synthases, nitrate, nitrite, nitrotyrosine, tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), interleukin- 6 (IL-6) and CD154. After CR there was an increase in maximal oxygen consumption (21.2 ± 1.4 vs 25.7 ± 2.5 mL/kg/min, P 0.0001); work load (116.2 ± 14.9 vs 140 ± 17 W, P 0.0001); pulmonary ventilation (59.8 ± 7,5 vs 73.8 ± 11.6 L/min, P 0.0001); anaerobic threshold (53.8% ± 3.5% vs 60.2% ± 3.3% of maximal VO |
| Databáze: | OpenAIRE |
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