Effects of catecholamines on the coronary circulation in the Langendorff-type transplanted dog heart
| Autor: | R. W. Giles, David E.L. Wilcken, H. J. Paoloni, E. Eikens, W. E. Glover |
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| Rok vydání: | 1975 |
| Předmět: |
Inotrope
medicine.medical_specialty Epinephrine Physiology Propranolol Norepinephrine (medication) Contractility Norepinephrine Coronary circulation Catecholamines Dogs Heart Rate Coronary Circulation Physiology (medical) Isoprenaline Internal medicine Animals Transplantation Homologous Medicine Infusions Parenteral skin and connective tissue diseases business.industry Isoproterenol Heart Blood flow Myocardial Contraction medicine.anatomical_structure Ventricle Anesthesia Cardiology Heart Transplantation sense organs Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiovascular Research. 9:779-787 |
| ISSN: | 0008-6363 |
| DOI: | 10.1093/cvr/9.6.779 |
| Popis: | Intracoronary administration of isoprenaline, adrenaline, and the noradrenaline in the Langendorff-type transplanted dog heart transiently decreased coronary blood flow measured from the inflow vessel; flow then increased. The reduction in coronary flow coincided with increased myocardial contractility and was prevented by keeping the left ventricle empty. Propranolol prevented changes in flow and contractility. It is concluded that positive inotropic changes result in the ejection of accumulated Thesbesian flow from the ventricle and affect coronary flow measurements and that the interpretation of flow changes requires a steady state. |
| Databáze: | OpenAIRE |
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