Determinants of psychotropic drug usage in a general intensive care unit

Autor: Frederik W Santman, Frans G. Zitman, Eibert R. Heerdink, J.J. Stolker, Sigrid E.J Pullen, Yechiel A. Hekster, Hubert G. M. Leufkens
Rok vydání: 1998
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
Adolescent
law.invention
Hospitals
University
Time pattern
Rational Use of Drugs and Pharmaco-epidemiology
Age Distribution
Patient Admission
Disease severity
law
medicine
Humans
Medical prescription
Daily exposure
Practice Patterns
Physicians'
Sex Distribution
Intensive care medicine
APACHE
Aged
Netherlands
Retrospective Studies
Aged
80 and over
Psychotropic Drugs
business.industry
Critically ill
Public health
Length of Stay
Middle Aged
Intensive care unit
development of diagnostic criteria and of an inventory for the assessment of the severity of dependence [The syndrome of benzodiazepine dependency]
Drug Utilization
Psychiatry and Mental health
Intensive Care Units
Psychotropic drug
Emergency medicine
Female
Rationeel Geneesmiddelengebruik en Farmaco-epidemiologie
business
Ontwikkeling van diagnostische criteria en van een zelfbeoordelingsvragenlijst voor de ernst van de afhankelijkheid [Het benzodiazepine-afhankelijkheidssyndroom]
Zdroj: General Hospital Psychiatry, 20, pp. 371-376
General Hospital Psychiatry, 20, 371-376
ISSN: 0163-8343
Popis: During a 3-month period, determinants of psychotropic drug utilization (sex, age, length of stay, reason for admission, disease severity) and data on psychotropic consumption (type of medication—antidepressants, benzodiazepines and antipsychotics—dosage and length of treatment) were retrospectively collected in a general intensive care unit of a Dutch university hospital. Daily exposure to psychotropics was standardized in number of Defined Daily Doses (DDD). Benzodiazepines were used by 35.8% of all patients (137) during their stay in the ICU whereas 17.5% of all patients used a neuroleptic agent. Antidepressants were hardly prescribed. High doses of benzodiazepines (9.9 DDDs) and low doses of antipsychotics (0.5 DDDs) were prescribed, which probably reflect the unusual nature of this critically ill group of patients compared with the reference group for DDD’s. Clear patterns of determinants of psychotropic drug use in ICU patients were found and both benzodiazepines, antipsychotics and combined use of these agents could be associated with the determinants assessed. The time patterns we found in terms of length of stay give clues for further investigations in order to rationalize psychotropic drug use in the management of severely ill and complex patients.
Databáze: OpenAIRE
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