Association between GnRH Receptor Polymorphisms and Luteinizing Hormone Levels for Low Ovarian Reserve Infertile Women
| Autor: | Chung-Hsien Liu, Shun-Long Weng, Shu-Ling Tzeng, Shun-Fa Yang, Chun-Chia Huang, Chun-I Lee, Tsung-Hsien Lee, Maw-Sheng Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Anti-Mullerian Hormone Pituitary gland endocrine system diseases Health Toxicology and Mutagenesis Gonadotropin-Releasing Hormone 0302 clinical medicine single nucleotide polymorphism GnRH antagonist Receptor Ovarian Reserve GnRH agonist 030219 obstetrics & reproductive medicine biology GNRHR Anti-Müllerian hormone female genital diseases and pregnancy complications POSEIDON criteria medicine.anatomical_structure Medicine Female Luteinizing hormone Infertility Female hormones hormone substitutes and hormone antagonists Agonist medicine.medical_specialty endocrine system medicine.drug_class Article 03 medical and health sciences poor responders Internal medicine medicine Humans Ovarian reserve business.industry GnRH receptor Public Health Environmental and Occupational Health Luteinizing Hormone assisted reproduction technology 030104 developmental biology Endocrinology anti-Müllerian hormone Case-Control Studies biology.protein Follicle Stimulating Hormone business Receptors LHRH Hormone |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 18 Issue 13 International Journal of Environmental Research and Public Health, Vol 18, Iss 7006, p 7006 (2021) |
| ISSN: | 1660-4601 1040-7022 |
| DOI: | 10.3390/ijerph18137006 |
| Popis: | The choice of ovarian stimulation protocols in assisted reproduction technology (ART) cycles for low ovarian reserve patients is challenging. Our previous report indicated that the gonadotrophin-releasing (GnRH) agonist (GnRHa) protocol is better than the GnRH antagonist (GnRHant) protocol for young age poor responders. Here, we recruited 269 patients with anti-Müllerian hormone (AMH) < 1.2 ng/mL undergoing their first ART cycles for this nested case-control study. We investigated the genetic variants of the relevant genes, including follicular stimulating hormone receptor (FSHR rs6166), AMH (rs10407022), GnRH (rs6185), and GnRH receptor (GnRHR rs3756159) in patients < 35 years (n = 86) and patients ≥35 years of age (n = 183). Only the genotype of GnRHR (rs3756159) is distributed differently in young (CC 39.5%, CT/TT 60.5%) versus advanced (CC 24.0%, CT/TT 76.0%) age groups (recessive model, p = 0.0091). Furthermore, the baseline luteinizing hormone (LH) levels (3.60 (2.45 to 5.40) vs. 4.40 (2.91 to 6.48)) are different between CC and CT/TT genotype of GnRHR (rs3756159). In conclusion, the genetic variants of GnRHR (rs3756159) could modulate the release of LH in the pituitary gland and might then affect the outcome of ovarian stimulation by GnRHant or GnRHa protocols for patients with low AMH levels. |
| Databáze: | OpenAIRE |
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