Effects of SCH-23390 and Raclopride on Cocaine Discrimination in Male and Female Wistar Rats
| Autor: | Frans van Haaren, Karen G. Anderson |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Stimulus generalization medicine.medical_treatment Clinical Biochemistry Pharmacology Toxicology Biochemistry Discrimination Learning Behavioral Neuroscience chemistry.chemical_compound Discrimination Psychological Cocaine Dopamine Uptake Inhibitors Estrus Dopamine medicine Animals Rats Wistar Saline Biological Psychiatry Estrous cycle Raclopride Sex Characteristics SCH-23390 Dose-Response Relationship Drug Receptors Dopamine D1 Dopamine antagonist Antagonist Benzazepines Rats Dopamine D2 Receptor Antagonists Generalization Stimulus chemistry Dopamine Antagonists Female Cues Psychology medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 65:671-675 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(99)00256-7 |
| Popis: | Male and female rats were trained to discriminate 10.0 mg/kg cocaine from saline in a two-lever discrimination task. Injection-appropriate responding was reinforced by food pellet presentation on a tandem random-interval 30-s fixed-ratio 10 schedule. Generalization testing was conducted in extinction 10 min following an injection of saline, 1.0, 3.0, 5.6, or 10.0 mg/kg cocaine. No differences in the generalization gradients and ED(50)s were observed between male and female rats. Following the determination of the cocaine generalization gradient, the dopamine D(1) antagonist SCH-23390 (0.01-0.10 mg/kg) and the dopamine D(2) antagonist raclopride (0.1-1.6 mg/kg) were administered (independently) prior to the injection of the training dose of cocaine (10.0 mg/kg). Cocaine-antagonism tests were conducted in extinction. It was found, for each dopamine antagonist, that as the dose increased, the percentage of cocaine-appropriate responding decreased. No sex differences were observed between these generalization gradients. |
| Databáze: | OpenAIRE |
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