Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents
| Autor: | Ting Kuang Yeh, Chun-Yen Chang, Ting Chi Yeh, Li Ching Lee, Pei-Jung Lin, Ying Chun Cho |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Article Subject Adolescent Genotype Emotions Population Exploratory research Polymorphism Single Nucleotide Receptors N-Methyl-D-Aspartate lcsh:RC321-571 Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine medicine Humans SNP Social Behavior Psychiatry education lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Genetic Association Studies Depression (differential diagnoses) education.field_of_study biology GRIN1 030104 developmental biology Neurology Adolescent Behavior biology.protein NMDA receptor GRIN2A Female GRIN2B Neurology (clinical) Psychology 030217 neurology & neurosurgery Research Article Clinical psychology |
| Zdroj: | Neural Plasticity Neural Plasticity, Vol 2016 (2016) |
| ISSN: | 1687-5443 2090-5904 |
| DOI: | 10.1155/2016/6851592 |
| Popis: | Considerable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders. Previous exploratory studies have been primarily based on evidence from patients and have rarely sampled the general population. This exploratory study examined the relationship of single-nucleotide polymorphism (SNP) variations in the genes encoding the NMDA receptor (i.e.,GRIN1, GRIN2A, GRIN2B, GRIN2C, andGRIN2D) with emotion and social behavior in adolescents. For this study, 832 tenth-grade Taiwanese volunteers were recruited, and their scores from the Beck Youth Inventories were used to evaluate their emotional and social impairments. Based on these scores,GRIN1(rs4880213) was significantly associated with depression and disruptive behavior. In addition,GRIN2B(rs7301328) was significantly associated with disruptive behavior. Because emotional and social impairment greatly influence learning ability, the findings of this study provide important information for clinical treatment and the development of promising prevention and treatment strategies, especially in the area of psychological adjustment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text