Ventilatory effects produced by the i.v. administration of incremental doses of thiopentone in the dog
| Autor: | M. Galliot, F. Ferracci, C. Dauthier, J.F. Boitier, J.H. Gaudy |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Respiratory rate Dogs Respiration Reflex Medicine Animals Expiration Thiopental Lung biology Dose-Response Relationship Drug business.industry Pulmonary Gas Exchange Fissipedia biology.organism_classification Anesthesiology and Pain Medicine Anesthesia Anesthetic Breathing Anesthesia Intravenous Airway business medicine.drug |
| Zdroj: | British journal of anaesthesia. 55(10) |
| ISSN: | 0007-0912 |
| Popis: | Ventilation, ventilatory pattern and ventiflatory drive were studied in five dogs during the administration of increasing blood concentrations of thiopentone. Ventilation (Ve, RR, Vt) and blood-gas tensions (pHa, Paco2, Pao2) were measured. Ventilatory pattern (VT, TI, TE, Ttot) and ventilatory drive (VT/TI) and occlusion pressure) were analysed. Occlusions of the airway were performed at end-inspiration and at end-expiration. Thiopentone produced a biphasic action on respiratory rate, ranging from tachypnoea during light anaesthesia to a progressive slowing of respiration with deepening anaesthesia. The Hering-Breuer reflex did not seem to be modified by the level of anaesthesia, whereas the central mechanisms which modulate the duration of inspiration and of expiration, were perturbed. |
| Databáze: | OpenAIRE |
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