Influence of high density lipoprotein (HDL), prepared from human blood, on prostanoid formation, serum and tissue lipids and development of arteriosclerosis in cholesterol rich fed rabbits
| Autor: | A. Beitz, Ch. Szymanski, F.W. Rath, H.-J. Mest, B. Kuklinski, B. Oswald, Taube C, J. Beitz |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Arteriosclerosis Clinical Biochemistry Arachidonic Acids Biology Pathogenesis chemistry.chemical_compound High-density lipoprotein Internal medicine medicine.artery medicine Animals Humans Platelet Aorta Cholesterol Reverse cholesterol transport Lipid metabolism Cell Biology Lipid Metabolism medicine.disease Endocrinology chemistry Prostaglandins Diet Atherogenic lipids (amino acids peptides and proteins) Rabbits Lipoproteins HDL |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 40:211-215 |
| ISSN: | 0952-3278 |
| DOI: | 10.1016/0952-3278(90)90100-y |
| Popis: | The i.v. administration of high density lipoprotein (HDL) into cholesterol fed rabbits decreased statistically significantly the serum level of total cholesterol and of low density lipoprotein cholesterol after a feeding period of 8 weeks. These diminished levels of cholesterol were associated with a statistically significant reduction in the levels of cholesterol esters in kidneys and platelets but not in hepatic tissue or in aorta. Macroscopically detectable arteriosclerosis was not statistically significantly diminished. The formation of prostanoids by the aorta remained unchanged. The atherogenic role of immunologic factors acting against the heterologous HDL may have compensated for the antiatherogenic HDL action on plasma and tissue lipids. |
| Databáze: | OpenAIRE |
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