Ten-Day Sequential Therapy as First-line Treatment forHelicobacter pyloriInfection in Korea: A Retrospective Study
| Autor: | Jin H. Hwang, Jin J. Kim, Jung Won Lee, Dong H. Lee, In S. Song, Hyun Chae Jung, Jin Wook Kim, Byeong Jun Song, Jung H. Kwon, Nayoung Kim, Sook-Hyang Jeong, Young Suk Park, Sang Hyup Lee |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Rabeprazole Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Helicobacter Infections Pharmacotherapy Clarithromycin Metronidazole Internal medicine medicine Humans Urea Adverse effect Retrospective Studies Korea Helicobacter pylori biology business.industry Amoxicillin Proton Pump Inhibitors General Medicine Middle Aged biology.organism_classification Anti-Bacterial Agents Treatment Outcome Infectious Diseases Breath Tests Female Gastritis medicine.symptom business medicine.drug |
| Zdroj: | Helicobacter. 15:148-153 |
| ISSN: | 1523-5378 1083-4389 |
| DOI: | 10.1111/j.1523-5378.2010.00748.x |
| Popis: | Background and Aims: The eradication rate of proton-pump inhibitor-based triple therapy for Helicobacter pylori infection is low due to increasing antibiotics resistance, especially clarithromycin. Recently, it was reported in Europe that a 10-day sequential strategy produced good outcomes. The aim of this study was to assess the efficacy of sequential therapy as first-line treatment for eradication of H. pylori in clinical practice in Korea. Materials and Methods: A total of 98 patients (mean age 55.2 years and male 47, female 51) with proven H. pylori infection received 10-day sequential therapy (20 mg of rabeprazole, and 1 g of amoxicillin, twice daily for the first 5 days, followed by 20 mg of rabeprazole, 500 mg of clarithromycin, and 500 mg of metronidazole, twice daily for the remaining 5 days). Eradication was evaluated 4 weeks later, after completion of treatment by 13C-urea breath testing. Eradication rates were calculated by intention-to-treat (ITT) and by per protocol (PP). Compliance and adverse events were also assessed in study group. Results: The eradication rate of sequential therapy was 91.8% (90/98) by ITT and same result was reported by PP analysis (89/97). The study group consisted of 66 H. pylori associated gastritis, 7 gastric ulcer, and 25 duodenal ulcer patients (67.3%, 7.1%, 25.5%, respectively). Mild adverse events happened frequently (21.4%) but the treatment was well tolerable. The most common adverse event was a bitter taste (9.2%) followed by nausea and diarrhea (4.1%). Conclusions: Ten-day sequential therapy is found to effectively eradicate H. pylori infection as first-line treatment in Korea. |
| Databáze: | OpenAIRE |
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