Effect of passive immunization by anti-gingipain IgY on periodontal health of dogs
| Autor: | Rie Isoda, Yoshikatsu Kodama, Van Sa Nguyen, El-Sayed M. Ibrahim, Kouji Umeda, Rahman A. K. M. Shofiqur |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Gingival and periodontal pocket
medicine.disease_cause Gingipain Gingivitis stomatognathic system IgY lcsh:Zoology medicine lcsh:QL1-991 Adverse effect Periodontitis Porphyromonas gingivalis biology business.industry Calculus (dental) biology.organism_classification medicine.disease stomatognathic diseases Pet Immunology Porphyromonas gulae medicine.symptom business |
| Zdroj: | Veterinary Science Development, Vol 1, Iss 1, Pp e8-e8 (2011) |
| ISSN: | 2038-9701 2038-9698 |
| Popis: | Anti-gingipain IgY (IgY-GP), known as hyperimmune γ-livetin from egg yolk, inhibits the enzyme activity, growth and adherence of Porphyromonas gingivalis to gingival epithelial cells. Our objective was to evaluate the efficacy of IgY-GP on periodontal health of dogs. IgY-GP was prepared from the egg yolk of hens immunized with the gingipain from Porphyromonas gingivalis ATCC 33277. Two in vivo trial models were conducted on 15 adult dogs with periodontitis by giving IgY-GP-supplemented dog feed for 8 weeks and direct application of the IgY in dental ointment to the periodontal pockets at weekly interval for 4 weeks. Clinical parameters including gingivitis, periodontitis, oral health index, bleeding on probe (BOP), pocket depth (PD), and dental calculus removal pattern for selected premolar teeth were recorded at baseline, 4 and 8 weeks post treatment.IgY-GP showed strong cross-reactivity with gingipain from Porphyromonas gulae and inhibited the enzyme activity in vitro. In the dog trials, IgY-GP resulted in significant improvement of oral health parameters including gingivitis and periodontitis scores, BOP, dental calculus removal. No adverse events during and after antibody applications were noted. Oral immunotherapy by using IgY-GP is a new promising alternative to conventional preventive and therapeutic methods to improve oral health status in dogs. |
| Databáze: | OpenAIRE |
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