Intraocular Penetration of Rosoxacin in Rabbits
| Autor: | Lowell D. Zeleznick, Charles D. Hulem, Susan E. Old, Irving H. Leopold |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Conjunctiva genetic structures Quinolones Eye Permeability Retina Injections Anti-Infective Agents Ophthalmology medicine Animals Rosoxacin 4-Quinolones Enzymatic digestion Choroid business.industry Microbiological assay Optic Nerve eye diseases medicine.anatomical_structure Anesthesia Injections Intravenous Quinolines Optic nerve Female Rabbits sense organs business medicine.drug Intraocular penetration |
| Zdroj: | Archives of Ophthalmology. 100:646-649 |
| ISSN: | 0003-9950 |
| DOI: | 10.1001/archopht.1982.01030030648025 |
| Popis: | • Rosoxacin, a new synthetic antimicrobial agent, has a wide spectrum of activity that may prove beneficial in the treatment of ocular infections. To determine the penetration of rosoxacin into ocular tissues and serum of the rabbit after topical, subconjunctival, and intravenous (IV) administration, rosoxacin levels were measured using a microbiological assay after enzymatic digestion of the ocular tissues. Quantities of rosoxacin that should prove to be of therapeutic value were detectable in the anterior segment of the eye after topical or subconjunctival administration. Subconjunctival administration also resulted in high levels in the retina and choroid area and in the optic nerve. Low levels were detected in the retina and choroid 15 minutes following IV injection; however, no detectable levels were found in the ocular tissues after this period. |
| Databáze: | OpenAIRE |
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