An unusual bidentate methionine ruthenium(II) complex: photo-uncaging and antimicrobial activity
| Autor: | Aurideia P. de Sousa, Beatriz Pinheiro Bezerra, Edson Holanda Teixeira, Eduardo H.S. Sousa, Alda K.M. Holanda, Luiz Gonzaga de França Lopes, Alejandro Ayala, Mayron Alves de Vasconcelos, Patrícia H. R. Martins, Ana C. S. Gondim |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Staphylococcus aureus Denticity Light chemistry.chemical_element Microbial Sensitivity Tests 010402 general chemistry 01 natural sciences Biochemistry Ruthenium Inorganic Chemistry chemistry.chemical_compound Methionine Staphylococcus epidermidis Coordination Complexes Salmon Animals DNA Cleavage Aqueous solution biology 010405 organic chemistry Chemistry Photodissociation DNA biology.organism_classification Photochemical Processes Combinatorial chemistry Spermatozoa 0104 chemical sciences Anti-Bacterial Agents Reagent |
| Zdroj: | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 25(3) |
| ISSN: | 1432-1327 |
| Popis: | The cis-[Ru(bpy)2(Met)](PF6)2 complex, where Met = l-methionine and bpy = 2,2′-bipyridine, was prepared and fully characterized. This complex was subjected to blue and green light photolysis (453 and 505 nm, respectively) in aqueous solution, leading to the release of methionine and formation of the cis-[Ru(bpy)2(H2O)2]2+ ion. This latter photoproduct was shown to subsequently interact with DNA, while DNA photocleavage was noticed. In agreement with these reactivities, this compound exhibited an exciting antibacterial action, particularly against Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, which was enhanced upon blue light irradiation. Altogether, these results showed that our strategy was successful in producing light-triggered DNA-binding agents with pharmacological potential and a likely blocking reagent for efficient peptide chemistry formation. |
| Databáze: | OpenAIRE |
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