Neonatal lupus erythematosus presenting as Stevens-Johnson syndrome
Autor: | Fang-Ying Wang, Wen-Hung Chung, Ren-Feng Liu, Chun-Bing Chen, Chin-Yi Yang |
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Rok vydání: | 2018 |
Předmět: |
Pathology
medicine.medical_specialty Lupus erythematosus business.industry Transplacental Stevens johnson Dermatology lcsh:RL1-803 Maternal autoantibodies medicine.disease stomatognathic diseases 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030225 pediatrics lcsh:Dermatology Medicine Neonatal lupus erythematosus skin and connective tissue diseases business Positive serology Direct fluorescent antibody Anti-SSA/Ro autoantibodies |
Zdroj: | Dermatologica Sinica, Vol 36, Iss 2, Pp 97-100 (2018) |
ISSN: | 1027-8117 |
Popis: | Neonatal lupus erythematosus (NLE) is a rare acquired condition caused by the transplacental passage of maternal autoantibodies. It is characterized by cutaneous, cardiac, hepatobiliary, hematological and neurological involvement. Cutaneous findings of NLE are variable, but few reports in the literature describe the presence of erosions or epidermal loss in NLE. Herein, we describe the case of an infant with NLE presenting as Stevens-Johnson syndrome (SJS), with cardiac, hematologic, hepatobiliary and neurologic abnormalities. The characteristic features by which to differentiate SJS-like NLE from infant SJS include subacute course, cardiac abnormalities, positive serology tests and direct immunofluorescence, histopathologic findings with melanin incontinence, periadnexal infiltrates, and mucin deposit. Though rare, it is important to consider lupus erythematosus as a potential cause of acute syndrome with focal epidermal necrosis or pan-epidermolysis. Keywords: Epidermolysis, Neonatal lupus erythematosus, Stevens-Johnson syndrome |
Databáze: | OpenAIRE |
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