Transient aplastic crisis triggered by parvovirus B19 in a family with hereditary spherocytosis
| Autor: | Delphine Chiffre, Patricia Aguilar-Martinez, Perrine Mahe, Léa Domitien, Vincent Foulongne, Laure Vincent, Neila Arrada, Nicolas Cilla |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Blood transfusion medicine.medical_treatment viruses 030106 microbiology Context (language use) Parvovirus B19 Hereditary spherocytosis Infectious and parasitic diseases RC109-216 Article 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Medicine Medical history 030212 general & internal medicine biology business.industry Parvovirus virus diseases medicine.disease biology.organism_classification Pancytopenia Red blood cell Infectious Diseases medicine.anatomical_structure Immunology biology.protein Antibody Erythroblastopenia business |
| Zdroj: | IDCases, Vol 21, Iss, Pp e00802-(2020) IDCases |
| ISSN: | 2214-2509 |
| Popis: | Acute parvovirus B19 infection may lead to erythroblastopenia crisis in patients with underlying red blood cells disorders. We report herein an uncommon concomitant transient aplastic crisis in a mother and her daughter, both affected by hereditary spherocytosis. The diagnosis was confirmed by the detection of a very high parvovirus B19 DNA load in both the mother’s and daughter’s sera, associated with the presence of parvovirus B19 specific immunoglobulin-M antibodies. This rapid etiologic diagnosis allowed to save bone marrow sampling, although blood transfusion was required regarding the severe anemia associated with pancytopenia. Our observation illustrates first line parvovirus B19 hypothesis in the context of transient aplastic crisis and that contagiousness in household contacts should be considered in family with a medical history of red blood cell pathology. |
| Databáze: | OpenAIRE |
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