Inflammation in myocardial injury- Stem cells as potential immunomodulators for myocardial regeneration and restoration
| Autor: | Vimalraj Selvaraj, Preethi Vincent, Shibi Muralidar, Balamurugan Palaniappan, Saravanan Sekaran, Senthil Visaga Ambi, Sajini Vadivel, Diraviyam Thirumalai |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pluripotent Stem Cells Neutrophils medicine.medical_treatment Myocardial Infarction Regenerative Medicine 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Humans Regeneration Myocardial infarction General Pharmacology Toxicology and Pharmaceutics Induced pluripotent stem cell Complement Activation Cell Proliferation Inflammation business.industry Regeneration (biology) Myocardium Mesenchymal stem cell Mesenchymal Stem Cells General Medicine Stem-cell therapy medicine.disease Embryonic stem cell Fibrosis Oxidative Stress 030104 developmental biology Cancer research Stem cell business Adult stem cell Stem Cell Transplantation |
| Zdroj: | Life sciences. 250 |
| ISSN: | 1879-0631 |
| Popis: | The ineffective immunosuppressant's and targeted strategies to neutralize inflammatory mediators have worsened the scenario of heart failure and have opened many questions for debate. Stem cell therapy has proven to be a promising approach for treating heart following myocardial infarction (MI). Adult stem cells, induced pluripotent stem cells and embryonic stem cells are possible cell types and have successfully shown to regenerate damaged myocardial tissue in pre-clinical and clinical studies. Current implications of using mesenchymal stem cells (MSCs) owing to their immunomodulatory functions and paracrine effects could serve as an effective alternative treatment option for rejuvenating the heart post MI. The major setback associated with the use of MSCs is reduced cell retention, engraftment and decreased effectiveness. With a few reports on understanding the role of inflammation and its dual effects on the structure and function of heart, this review focuses on these missing insights and further exemplifies the role of MSCs as an alternative therapy in treating the pathological consequences in myocardial infarction (MI). |
| Databáze: | OpenAIRE |
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