Risk Factors and Gene Type for Infections of MRSA in Diabetic Foot Patients in Tianjin, China
| Autor: | Shuhong Feng, Penghua Wang, Yuejie Chu, Xuemei Li, Ding Min, Xu Jun |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Methicillin-Resistant Staphylococcus aureus China Genotype medicine.drug_class Antibiotics Microbial Sensitivity Tests medicine.disease_cause Staphylococcal infections Microbiology Risk Factors medicine Humans business.industry Pseudomonas aeruginosa SCCmec General Medicine Middle Aged Staphylococcal Infections respiratory system biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease Methicillin-resistant Staphylococcus aureus Diabetic foot Diabetic Foot Case-Control Studies Female Surgery sense organs business Methicillin Susceptible Staphylococcus Aureus |
| Zdroj: | The International Journal of Lower Extremity Wounds. 12:106-112 |
| ISSN: | 1552-6941 1534-7346 |
| DOI: | 10.1177/1534734613489991 |
| Popis: | The objective was to study risk factors and gene type of DF patients infected with MRSA. A total of 429 DF patients were recruited. The patients with S aureus infections were divided into MRSA and MSSA groups. MRSA were genotyped by SCCmec. pvl and lukE-lukD were detected. A total of 559 pathogens were isolated from them, with G+ bacteria firstly(59.0%), followed G- bacilli (37.7%) and true fungi (3.3%). The 3 most frequently isolated pathogens were S aureus (35.2%), S epidermidis (12.3%), and Pseudomonas aeruginosa (11.2%). SCCmec III MRSA and SCCmec IVa MRSA had the same antibacterial spectrum. mecA positive rate was 100%. lukE-lukD and pvl positive rates were 100% and 0%, respectively. 28 strains belonged to SCCmec III and the others belonged to SCCmec IVa. The G+ cocci were the main pathogens, S aureus and S epidermidis were predominant among them. Antibiotic usage in 6 months prior to hospitalization, long course of ulcer, osteomyelitis and hypoproteinemia are risk factors for MRSA. SCCmec IVa is high in proportion to MRSA isolates, suggesting that CA-MRSA has become major pathogen of DF infection. All the MRSA were harboring lukE-lukD, which has been reported to present poor leucotoxin compared to pvl, and may be a response to atypical local inflammatory reaction in DF infection. |
| Databáze: | OpenAIRE |
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