Deafness and prolonged neuromuscular blockade following single-dose peritoneal neomycin irrigation
| Autor: | Amer A. Quaddoura, Timothy B. Gilbert, Stephen C. Jacobs |
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| Rok vydání: | 1998 |
| Předmět: |
Time Factors
Premedication medicine.medical_treatment Deafness Nephrectomy Clonazepam Peritoneal dialysis Peritoneal cavity Postoperative Complications Ototoxicity Risk Factors Laparotomy medicine Humans Peritoneal Lavage GABA Modulators Antibacterial agent Neuromuscular Blockade business.industry Clindamycin Neomycin General Medicine Middle Aged medicine.disease Anti-Bacterial Agents Cochlea Anesthesiology and Pain Medicine medicine.anatomical_structure Concomitant Anesthesia Kidney Failure Chronic Female Respiratory Insufficiency business Peritoneal Dialysis medicine.drug |
| Zdroj: | Canadian Journal of Anaesthesia. 45:568-570 |
| ISSN: | 1496-8975 0832-610X |
| DOI: | 10.1007/bf03012710 |
| Popis: | A case of deafness is reported in a patient undergoing bilateral nephrectomy after single irrigation of the peritoneal cavity with a neomycin containing solution for surgical prophylaxis.In this patient, profound, late-postoperative deafness was heralded by prolonged neuromuscular blockade and respiratory insufficiency. Additional risk factors for ototoxicity in this particular patient included the presence of end-stage renal disease requiring daily peritoneal dialysis and, possibly, the concomitant use of clonazepam and clindamycin.Antibiotic irrigation solutions containing neomycin may produce unwanted adverse systemic effects of deafness and prolonged neuromuscular blockade, even with only brief application within the peritoneal cavity. Concurrent end-stage renal disease, visceral inflammation from chronic dialysis and laparotomy, and the concomitant use of other medications may have contributed to these unwanted effects. |
| Databáze: | OpenAIRE |
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