The role of Na,K-ATPase inhibitor on pressor responsiveness in patients with benign essential hypertension
| Autor: | Mitsuhiro Nishimura, Osamu Iimura, Hiroshi Kobayakawa, Tohru Hasegawa, Hiroaki Komura, Kenjiro Kikuchi, Izumi Yamaji, Akihiko Nozawa |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Endogeny Blood Pressure Pressoreceptors Na-K ATPase inhibitor Ouabain Norepinephrine (medication) Norepinephrine Heart Rate Internal medicine Internal Medicine Medicine Humans In patient Benign Essential Hypertension Calcium metabolism business.industry Middle Aged medicine.disease Endocrinology Pathophysiology of hypertension Hypertension Injections Intravenous Calcium Female Sodium-Potassium-Exchanging ATPase business medicine.drug |
| Zdroj: | American journal of hypertension. 3(3) |
| ISSN: | 0895-7061 |
| Popis: | To clarify the role of Na,K-ATPase inhibitor in the enhanced pressor response to infused noradrenaline (NA-R) in patients with benign essential hypertension (EHT), NA-R, plasma noradrenaline concentration (PNA), and blood ionized calcium (Ca2+) were investigated before and after intravenous injection of ouabain in 15 normotensive subjects (NT) and 13 EHT. NA-R was enhanced by ouabain in both NT and EHT. The augmentation of NA-R following ouabain injection (delta NA-R) and % delta NA-R were significantly lower in EHT than in NT. Following ouabain injection, no significant change in PNA and blood Ca2+ was observed in both NT and EHT. NA-R negatively correlated with PNA and blood Ca2+, which were estimated just prior to noradrenaline infusion, before ouabain injection as well as after. After ouabain, the regression line between NA-R and PNA or blood Ca2+ shifted toward higher NA-R level in NT, unlike in EHT. These results suggest that an exogenous Na,K-ATPase inhibitor brings about a blunted enhancement of NA-R in EHT consistent with the presence of an endogenous Na,K-ATPase inhibitor in EHT. |
| Databáze: | OpenAIRE |
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