Chlamydia pneumoniae, but not Bartonella quintana, is associated with coronary heart disease: results of a French case-control study
| Autor: | F. Eb, P. Brouqui, Sékéné Badiaga, F. Paganelli, K. Barrau, M. Beghin, Philippe Parola |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty coronary artery serology chlamydia Coronary Disease medicine.disease_cause Serology Coronary artery disease Bartonella quintana Risk Factors Seroepidemiologic Studies Internal medicine Prevalence medicine Humans Chlamydiaceae coronary heart disease Risk factor cross-reaction Chlamydophila Infections Chlamydia biology business.industry Case-control study General Medicine Chlamydophila pneumoniae bacterial infections and mycoses biology.organism_classification medicine.disease Trench Fever Infectious Diseases Case-Control Studies Immunology bacteria France business |
| Zdroj: | Clinical Microbiology and Infection. 9:315-318 |
| ISSN: | 1198-743X |
| DOI: | 10.1046/j.1469-0691.2003.00508.x |
| Popis: | Serologic cross-reactivity has been demonstrated between Bartonella quintana and Chlamydia pneumoniae. Therefore, the association between antibodies to C. pneumoniae and coronary heart disease (CHD) as described in the literature may be due to antibodies cross-reacting with B. quintana. To investigate this hypothesis, we evaluated, in a case-control study, the prevalence of C. pneumoniae and B. quintana antibodies among 296 cases with angiographically significant artery lesions and 170 controls without angiographically demonstrable coronary artery disease. The prevalence of C. pneumoniae antibodies was higher among cases than among controls: 69% versus 49% (P < 0.001; OR 1.39; 95% CI (1.55; 3.52)). Multiple logistic regression demonstrated that C. pneumoniae seropositivity is an independent risk factor for CHD (adjusted OR 2.31; 95% CI (1.49; 3.60)). No statistically significant association was demonstrated between B. quintana seropositivity and CHD. Antibodies to both C. pneumoniae and B. quintana were found in nine subjects (seven cases and two controls), suggesting co-infection rather than cross-reactivity. |
| Databáze: | OpenAIRE |
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