Development of a Method for Simultaneous Analysis of Allergenic Flavoring Agents in Cigarettes and Quantitative Risk Assessment for Consumer Safety
| Autor: | Dal Woong Choi, Hyung Soo Kim, Dae Yong Jang, Ye Ji Koo, Kyung Min Lim, Eun Chul Pack |
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| Rok vydání: | 2021 |
| Předmět: |
Taste
food.ingredient capsule cigarette Health Toxicology and Mutagenesis media_common.quotation_subject Flavoring Agents TP1-1185 010501 environmental sciences Toxicology 01 natural sciences Consumer safety Cosmetics Article chemistry.chemical_compound Human health 0404 agricultural biotechnology food Medicine Food science 0105 earth and related environmental sciences media_common Chemical Health and Safety business.industry Chemical technology Food additive risk assessment food and beverages 04 agricultural and veterinary sciences equipment and supplies 040401 food science inhalation exposure chemistry allergenic flavoring agent business Menthol Risk assessment gas chromatography-tandem mass spectrometry |
| Zdroj: | Toxics Volume 9 Issue 4 Toxics, Vol 9, Iss 87, p 87 (2021) |
| ISSN: | 2305-6304 |
| Popis: | Flavoring agents are added to cigarettes to improve taste. There are mostly permitted food additives, but some of them are restricted for use in food, cosmetics, and toys, since they can cause allergic reactions. Previous studies have investigated the levels of flavoring agents in tobacco but none has focused on their content in filter tips and capsules. Moreover, no studies have assessed the risk of adding allergenic flavoring agents in cigarettes. Here, we developed and validated a simultaneous analysis method for 25 allergenic flavoring agents and menthol with gas chromatography–tandem mass spectrometry to determine levels of flavoring agents in the tobacco, filter tips, and capsules of 54 commercial cigarettes in Korea. All cigarettes contained at least one allergenic flavoring agent regardless of the inclusion of flavoring capsules. Importantly, the filter tips and the capsules contained higher levels of flavoring agents than tobacco, highlighting the importance of the quantification of flavoring agents in these parts of cigarettes. Nevertheless, the risk assessment based on their levels in cigarettes suggested that their exposure was maintained at a safe level. However, the risk assessed from maximum menthol, linalool, and cinnamaldehyde exceeded one-tenth of derived no-effect levels, suggesting the need for further studies on their risk to human health. |
| Databáze: | OpenAIRE |
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