Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea
| Autor: | Seon Do Hwang, Sungdo Park, Jung Yeon Heo, Jae Hoon Lee, Hae Kyung Lee, Yeong Seon Lee, Hye Won Jeong, Seung Hun Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Fever Isolation (health care) Case Report Q fever Polymerase Chain Reaction law.invention Serology lcsh:Infectious and parasitic diseases Mice Medical microbiology law RNA Ribosomal 16S Chlorocebus aethiops Republic of Korea medicine Animals Humans Serologic Tests lcsh:RC109-216 Vero Cells Polymerase chain reaction Aged Mice Inbred BALB C biology business.industry Incidence Febrile illness medicine.disease Coxiella burnetii biology.organism_classification bacterial infections and mycoses Culture isolation molecular sequencing electron microscopy Virology Infectious Diseases Parasitology bacteria business |
| Zdroj: | BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-5 (2020) BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| Popis: | Background The number of human Q fever cases in South Korea has been rapidly increasing since 2015. We report the first isolation of Coxiella burnetii in Korea in two patients who initially presented with non-specific febrile illness and were finally diagnosed with acute Q fever in South Korea. Case presentation Two adult patients with fever had serologic tests against C. burnetii initially negative, and polymerase chain reaction against 16S rRNA using whole blood was also negative. After bacterial amplification of C. burnetii in immune-depressed mice, we isolated C. burnetii from patients with acute Q fever. The isolates KZQ2 and KZQ3 were confirmed by polymerase chain reaction, nucleotide sequence analysis, and morphologic observation using a transmission electron microscope. Conclusions These results can help us understand the clinical and epidemiologic features of Q fever in South Korea. |
| Databáze: | OpenAIRE |
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