Cytokine--chemokine and apoptotic signatures in patients with hepatitis C
| Autor: | Lawrence Cohen, Patrick Marcellin, Cristhian Trepo, Hemda Schmilovitz-Weiss, Gad G. Katz, Izabella M. Malkiewicz, Marc Bourlière, Ross G. Cameron, Dominique Valla, Manuela G. Neuman, Jean-Pierre Benhamou, Ziv Ben-Ari, Mary Morgan |
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| Rok vydání: | 2006 |
| Předmět: |
Chemokine
Cirrhosis medicine.medical_treatment Hepatitis C virus Biopsy Inflammation Apoptosis Knodell Fibrosis Score medicine.disease_cause Severity of Illness Index Fibrosis Transforming Growth Factor beta Physiology (medical) medicine Humans fas Receptor Chemokine CCL5 Chemokine CCL2 biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Biochemistry (medical) Public Health Environmental and Occupational Health Interleukin-18 Nuclear Proteins General Medicine Hepatitis C Hepatitis C Chronic medicine.disease Interleukin-12 Microscopy Electron Cytokine Liver Immunology biology.protein Hepatocytes Cytokines Interleukin-2 medicine.symptom Chemokines business Biomarkers |
| Zdroj: | Translational research : the journal of laboratory and clinical medicine. 149(3) |
| ISSN: | 1931-5244 |
| Popis: | Cytokines and chemokines are proteins that play a critical role in the regulation of immunity and inflammation in patients with chronic Hepatitis C. The aim of our study was to correlate serum cytokines, chemokines and apoptosis in non-treated chronic hepatitis C patients with various degrees of inflammation and fibrosis. We studied 778 patients: 59 had low Knodell fibrosis score and low Knodell histological activity index; 372 had mild fibrosis and low histological activity index; 270 had moderate fibrosis and moderate histological activity index; and, 77 had high fibrosis and high histological activity index on their biopsy. Serum cytokines, chemokines and apoptosis were measured by enzyme-linked-immunosorbent-assay. Multivariate analysis was employed for statistical purposes. A positive correlation was seen between the degree of inflammation and tumor necrosis factor-alpha (TNF-alpha) levels (r = 0.92) in non-cirrhotic patients and between interleukin 2 in all patients (r = 0.85). Interleukin-8 increased significantly at higher histological activity indices and continued to increase in patients with cirrhosis. Transforming growth factor-beta (TGF-beta) levels increased significantly with the severity of fibrosis, but decreased in cirrhotics. In conclusion, cytokines, chemokines and apoptosis levels reflect the progression of inflammation and fibrosis in hepatitis C infected patients, but their signatures differ. |
| Databáze: | OpenAIRE |
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