Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum
| Autor: | Matsuo Ogawa, Makio Mogi, Dong-shen Fan, Kunihiko Ikeguchi, Imaharu Nakano, Toshiharu Nagatsu, Nami Shizuma, Akifumi Togari |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Dopamine Agents Caudate nucleus Striatum Drug Administration Schedule chemistry.chemical_compound Mice Internal medicine Basal ganglia medicine Neurotoxin Animals Nerve Growth Factors Injections Intraventricular business.industry General Neuroscience Putamen MPTP Interleukin Brain Corpus Striatum Mice Inbred C57BL Endocrinology Nerve growth factor nervous system chemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine business Interleukin-1 |
| Zdroj: | Neuroscience letters. 250(1) |
| ISSN: | 0304-3940 |
| Popis: | Interleukin (IL)-1beta and nerve growth factor (NGF) were measured for the first time in the brain (caudate nucleus and putamen, and frontal cortex) from control mice and mice treated with a parkinsonism-inducing neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), by highly-sensitive sandwich enzyme-linked immunosorbent assays (ELISAs) The concentrations of interleukin (IL)-1beta in the striatal regions were significantly higher in MPTP-treated mice than those in control mice treated with saline (P < 0.005), whereas those in the frontal cortex did not show significant differences between MPTP-treated and control mice. The present results agreed with our previous data on increased IL-1beta in the postmortem striatum from patients with Parkinson's disease (PD). In contrast, the concentrations of nerve growth factor (NGF) in the striatal regions were significantly lower in MPTP-treated mice, down to a 54% level of control mice (P < 0.05), but those in the frontal cortex did not show significant differences between MPTP-treated and control mice. Since NGF may play important roles as neurotrophic factors in the brain, the present results suggest that both the elevation of pro-inflammatory cytokine IL-1beta and the decrease of NGF in the dopaminergic striatal region of MPTP- treated mice may be related to neuronal cell death. |
| Databáze: | OpenAIRE |
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