Association of the ile405val mutation in cholesteryl ester transfer protein gene with risk of acute myocardial infarction
| Autor: | Dimitris J. Richter, John Gialafos, R.K. Mattu, George Andrikopoulos, F G Kardaras, Kostas Kappos, Michalis N. Zairis, Ewa Needham, C. Stefanadis, P.K. Toutouzas, Elias Gialafos, K E Paravolidakis, Stefanos G. Foussas, E N Karabinos, Polychronis E. Dilaveris, Evangelos G. Papasteriadis |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Genotype Myocardial Infarction Polymerase Chain Reaction Gastroenterology chemistry.chemical_compound High-density lipoprotein Gene Frequency Scientific Letters Internal medicine Cholesterylester transfer protein medicine Humans Myocardial infarction Risk factor Aged Glycoproteins Intermediate-density lipoprotein Analysis of Variance biology Cholesterol business.industry Genetic transfer medicine.disease Cholesterol Ester Transfer Proteins Endocrinology chemistry Low-density lipoprotein Mutation biology.protein lipids (amino acids peptides and proteins) Carrier Proteins Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart. 90:1336-1337 |
| ISSN: | 1355-6037 |
| DOI: | 10.1136/hrt.2003.019067 |
| Popis: | Cholesteryl ester transfer protein (CETP) not only regulates removal of excess cholesterol to the liver but also mediates the transfer of esterified hydrophobic cholesterol to the potentially atherogenic low density lipoprotein (LDL) and intermediate density lipoprotein (IDL) particles. The Ile405Val mutation in the CETP gene, caused by an A>G mutation in codon 405 of exon 14, which is located in chromosome 16, has been related to decreased activity of the enzyme,1 increased but possibly dysfunctional high density lipoprotein (HDL) cholesterol, and increased risk for ischaemic heart disease2 in white women. The primary objective of this specifically designed, prospective study was to examine the influence of the Ile405Val mutation on risk of acute myocardial infarction (AMI) in a low coronary risk white population. The GEMIG study (genetics and epidemiology of acute myocardial infarction in the Greek population) was designed to evaluate the genetic predisposition of myocardial infarction and prognosis after AMI in the Greek population. Nine cardiac departments in three cities (Athens, Piraeus, and Thesalonici) in Greece, and the Department of Biological Sciences of Warwick University, have participated in this study. Blood samples for genetic analyses and successful genotyping for the Ile405Val mutation occurred in 1625 patients, out of a total of 1749 consecutive eligible patients who had been enrolled in the GEMIG study between October 1997 and March 1999. The control group consisted of 805 adults (aged > 30 years old) who were randomly selected from the city catalogues. Blood samples for genetic analyses were obtained from 794 of … |
| Databáze: | OpenAIRE |
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