Evaluation of pharmacological activities of methanol extract of Ixora cuneifolia leaves
| Autor: | Solayman Hossain, M. Akhlatun Nure, Mst. Marium Begum, Tamanna Binte Huq, Minhazur Rahman, Azharul Islam, Tasnia Malik, Wali Reza, Munny Das, M. Sohanur Rahman, Emdadul Haque, Bikash Chandra Adhikary, Abeer Sarwar, Taslima Begum |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant medicine.drug_class DPPH medicine.medical_treatment Ixora Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Edema medicine Gallic acid General Environmental Science Traditional medicine biology Chemistry biology.organism_classification Surgery Carrageenan 030104 developmental biology Phytochemical 030220 oncology & carcinogenesis General Earth and Planetary Sciences medicine.symptom |
| Zdroj: | Clinical Phytoscience. 2 |
| ISSN: | 2199-1197 |
| Popis: | In the current study in vitro antioxidant, thrombolytic and in vivo analgesic, anti-inflammatory, anti-diarrheal activities of methanol extract of Ixora cuneifolia leaves (MEIL) were investigated. The antioxidant activity was determined by using DPPH free radical scavenging method at doses 25, 50, 100, 200, 400 and 800 μg/ml. Total phenolic content was determined at doses of 50, 100, 150, 200 and 250 μg/ml. Whereas thrombolytic activity was determined by clot lysis method. The analgesic activity was conducted in Swiss albino mice at doses of 250 and 500 mg/kg body weight by hot plate method and acetic acid induced writhing method. Carrageenan induced rat paw edema method was used to evaluate anti-inflammatory activity. For anti-diarrheal activity castor oil induced method was used at the same dose mentioned earlier. Initial phytochemical study revealed the presence of flavonoids, saponins, gums, terpenoids, steroids and reducing sugars. The extract possessed significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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