Identification of biomarker panels as predictors of severity in coronary artery disease

Autor: F. Dumont, Denguir Hichem, Habib Gamra, Hinda Chahed, Bruno Baudin, Fodha Abdelhak, Assia Ben Braiek
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
arterial hypertension
medicine.medical_specialty
medicine.medical_treatment
Coronary Artery Disease
tissue inhibitors of matrix metalloproteinases
Matrix metalloproteinase
Coronary Angiography
Severity of Illness Index
Coronary artery disease
Electrocardiography
03 medical and health sciences
0302 clinical medicine
Risk Factors
Diabetes mellitus
Internal medicine
Humans
Medicine
Inverse correlation
Aged
diabetes
medicine.diagnostic_test
business.industry
Computational Biology
matrix metalloproteinases
Stent
Original Articles
Cell Biology
Plasma levels
Middle Aged
Prognosis
medicine.disease
030104 developmental biology
ROC Curve
Case-Control Studies
030220 oncology & carcinogenesis
Cardiology
Molecular Medicine
Biomarker (medicine)
Female
Original Article
lipids (amino acids
peptides
and proteins)
Disease Susceptibility
business
apolipoproteins
Biomarkers
Zdroj: Journal of Cellular and Molecular Medicine
ISSN: 1582-4934
1582-1838
Popis: Matrix metalloproteinases (MMPs) are implicated in atherosclerotic plaque rupture and recondition. Specific tissue inhibitors (TIMPs) control MMP functions. Both MMPs and TIMPs are potential biomarkers of plaque instability. Elevated Apo‐CII and CIII and Apo‐E levels are recognized as cardiovascular disease risk factors. We aimed to establish the best blood biomarker panel to evaluate the coronary artery disease (CAD) severity. Plasma levels of MMP‐3 and MMP‐9, TIMP‐1 and TIMP‐2, Apo‐CII, Apo‐CIII and Apo‐E were measured in 472 patients with CAD evaluated by coronary angiography and electrocardiography, and in 285 healthy controls. MMP‐3 and MMP‐9 plasma levels in CAD patients were significantly increased (P
Databáze: OpenAIRE
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