An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype

Autor: Katri Räikkönen, Myriam Fornage, Jianxin Shi, Najaf Amin, Dale R. Nyholt, Jordan W. Smoller, Tõnu Esko, Wei Zhao, Carsten Horn, Andres Metspalu, Harold Snieder, Enrique Castelao, Luigi Ferrucci, Catharina A. Hartman, Thomas G. Schulze, Stanley I. Shyn, Joanne M. Murabito, James B. Potash, Cathryn M. Lewis, Karestan C. Koenen, Azmeraw T. Amare, Jari Lahti, Stephan Ripke, Michele L. Pergadia, Cornelia M. van Duijn, Michael Conlon O'Donovan, Markus M. Nöthen, Grant C.B. Sinnamon, Rudolf Uher, Roy H. Perlis, Qingqin S. Li, Hans-Jörgen Grabe, Johannes H. Smit, Bernhard T. Baune, Donald J. MacIntyre, Erin C. Dunn, Alexander Teumer, Gonneke Willemsen, Nicholas G. Martin, Udo Dannlowski, Karin Hek, Shaun Purcell, Toni-Kim Clarke, Toshiko Tanaka, Jorge A. Quiroz, Myrna M. Weissman, Andrew M. McIntosh, Kathryn L. Lunetta, Scott D. Gordon, David R. Weir, Daniel Umbricht, Marcella Rietschel, Zoltán Kutalik, Stephanie Williams, Michael Gill, Albert Hofman, Enrico Domenici, Margarita Rivera, Pamela A. F. Madden, Jingyun Yang, John P. Rice, Sandra Van der Auwera, Steven P. Hamilton, Georg Homuth, David A. Bennett, Stefan Kloiber, Sharon L.R. Kardia, Anders D. Børglum, Sven Cichon, Nese Direk, Jessica D. Faul, Susanne Lucae, Dorret I. Boomsma, Douglas Blackwood, Jouke-Jan Hottenga, Marilyn C. Cornelis, Erin B. Ware, Enda M. Byrne, Andrew C. Heath, Philip L. De Jager, Ole Mors, Karl-Heinz Ladwig, Bertram Müller-Myhsok, Thomas H. Mosley, Jennifer A. Smith, Tracy Air, Yuri Milaneschi, Glyn Lewis, Brenda W.J.H. Penninx, David J. Llewellyn, Gerard van Grootheest, Eco J. C. de Geus, Henning Tiemeier, Grant W. Montgomery, Martin Preisig, Katherine E. Tansey, Patrick F. Sullivan, Douglas F. Levinson, Henriette N. Buttenschøn, Gerome Breen, Johan G. Eriksson, Ayse Demirkan
Přispěvatelé: Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, APH - Mental Health, APH - Methodology, APH - Digital Health, Epidemiology, Child and Adolescent Psychiatry / Psychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Biological Psychology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Clinicum, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Medicum, Department of Psychology and Logopedics, Developmental Psychology Research Group
Jazyk: angličtina
Rok vydání: 2017
Předmět:
DISORDER
Netherlands Twin Register (NTR)
Linkage disequilibrium
SYMPTOMS
STRESS
CHARGE consortium
genetics [Depressive Disorder]
Genome-wide association study
3124 Neurology and psychiatry
0302 clinical medicine
Neoplasm Proteins/genetics
MINOR DEPRESSION
European Continental Ancestry Group/genetics
POPULATION
RISK
Genetics
education.field_of_study
HERITABILITY
Depression
Depressive symptoms
Depression/genetics
Acid Anhydride Hydrolases
Neoplasm Proteins
3. Good health
genetics [European Continental Ancestry Group]
Phenotype
fragile histidine triad protein
Major depressive disorder
genetics [Depression]
Psychology
515 Psychology
Population
genetics [White People]
Single-nucleotide polymorphism
Locus (genetics)
White People
Psychiatric Genomics Consortium
FHIT gene
03 medical and health sciences
SDG 3 - Good Health and Well-being
ddc:570
Depressive Disorder/genetics
NATIONAL COMORBIDITY SURVEY
medicine
Journal Article
Humans
SNP
genetics [Acid Anhydride Hydrolases]
Genetic Predisposition to Disease
ddc:610
education
Biological Psychiatry
Genetic association
Depressive Disorder
genetics [Neoplasm Proteins]
major depressive disorder
3112 Neurosciences
MAJOR DEPRESSION
medicine.disease
SUBTHRESHOLD DEPRESSION
030227 psychiatry
Acid Anhydride Hydrolases/genetics
Genetic Loci
030217 neurology & neurosurgery
Genome-Wide Association Study
Zdroj: Biological Psychiatry, 82(5), 322-329. Elsevier USA
Biological Psychiatry, 82(5), 322-329. Elsevier Inc.
Direk, N, Williams, S, Smith, J A, Ripke, S, Air, T, Amare, A T, Amin, N, Baune, B T, Bennett, D A, Blackwood, D H R, Boomsma, D, Breen, G, Buttenschøn, H N, Byrne, E M, Børglum, A D, Castelao, E, Cichon, S, Clarke, T-K, Cornelis, M C, Dannlowski, U, De Jager, P L, Demirkan, A, Domenici, E, van Duijn, C M, Dunn, E C, Eriksson, J G, Esko, T, Faul, J D, Ferrucci, L, Fornage, M, de Geus, E, Gill, M, Gordon, S D, Grabe, H-J, van Grootheest, G, Hamilton, S P, Hartman, C A, Heath, A C, Hek, K, Hofman, A, Homuth, G, Horn, C, Jan Hottenga, J, Kardia, S L R, Kloiber, S, Koenen, K, Kutalik, Z, Ladwig, K-H, Lahti, J, Levinson, D F, Lewis, C M, Lewis, G, Li, Q S, Llewellyn, D J, Lucae, S, Lunetta, K L, MacIntyre, D J, Madden, P A F, Martin, N G, McIntosh, A M, Metspalu, A, Milaneschi, Y, Montgomery, G W, Mors, O, Mosley, T H, Murabito, J M, Müller-Myhsok, B, Nöthen, M M, Nyholt, D R, O'Donovan, M C, Penninx, B W, Pergadia, M L, Perlis, R, Potash, J B, Preisig, M, Purcell, S M, Quiroz, J A, Räikkönen, K, Rice, J P, Rietschel, M, Rivera, M, Schulze, T G, Shi, J, Shyn, S I, Sinnamon, G C, Smit, J H, Smoller, J W, Snieder, H, Tanaka, T, Tansey, K E, Teumer, A, Uher, R, Umbricht, D, Van der Auwera, S, Ware, E B, Weir, D R, Weissman, M M, Willemsen, G, Yang, J, Zhao, W, Tiemeier, H & Sullivan, P F 2017, ' An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype ', Biological Psychiatry, vol. 82, no. 5, pp. 322-329 . https://doi.org/10.1016/j.biopsych.2016.11.013
Biological psychiatry 82(5), 322-329 (2017). doi:10.1016/j.biopsych.2016.11.013
Biological Psychiatry, 82(5), 322-329. ELSEVIER SCIENCE INC
Direk, N, Williams, S, Smith, J A, Ripke, S, Air, T, Amare, A T, Amin, N, Baune, B T, Bennett, D A, Blackwood, D H R, Boomsma, D, Breen, G, Buttenschøn, H N, Byrne, E M, Børglum, A D, Castelao, E, Cichon, S, Clarke, T, Cornelis, M C, Dannlowski, U, De Jager, P L, Demirkan, A, Domenici, E, Van Duijn, C M, Dunn, E C, Eriksson, J G, Esko, T, Faul, J D, Ferrucci, L, Fornage, M, Geus, E D, Gill, M, Gordon, S D, Grabe, H J, Grootheest, G V, Hamilton, S P, Hartman, C A, Heath, A C, Hek, K, Hofman, A, Homuth, G, Horn, C, Hottenga, J J, Kardia, S L R, Kloiber, S, Koenen, K, Kutalik, Z, Ladwig, K, Lahti, J, Levinson, D F, Lewis, C M, Lewis, G, Li, Q S, Llewellyn, D J, Lucae, S, Lunetta, K L, Macintyre, D J, Madden, P, Martin, N G, Mcintosh, A M, Metspalu, A, Milaneschi, Y, Montgomery, G W, Mors, O, Mosley, T H, Murabito, J M, Müller-myhsok, B, Nöthen, M M, Nyholt, D R, O’donovan, M C, Penninx, B W, Pergadia, M L, Perlis, R, Potash, J B, Preisig, M, Purcell, S M, Quiroz, J A, Räikkönen, K, Rice, J P, Rietschel, M, Rivera, M, Schulze, T G, Shi, J, Shyn, S, Sinnamon, G C, Smit, J H, Smoller, J W, Snieder, H, Tanaka, T, Tansey, K E, Teumer, A, Uher, R, Umbricht, D, Der Auwera, S V, Ware, E B, Weir, D R, Weissman, M M, Willemsen, G, Yang, J, Zhao, W, Tiemeier, H & Sullivan, P F 2016, ' An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2016.11.013
BIOLOGICAL PSYCHIATRY
Direk, N, Williams, S, Smith, J A, Ripke, S, Air, T, Amare, A T, Amin, N, Baune, B T, Bennett, D A, Blackwood, D H R, Boomsma, D, Breen, G, Buttenschøn, H N, Byrne, E M, Børglum, A D, Castelao, E, Cichon, S, Clarke, T-K, Cornelis, M C, Dannlowski, U, De Jager, P L, Demirkan, A, Domenici, E, van Duijn, C M, Dunn, E C, Eriksson, J G, Esko, T, Faul, J D, Ferrucci, L, Fornage, M, de Geus, E, Gill, M, Gordon, S D, Grabe, H J, van Grootheest, G, Hamilton, S P, Hartman, C A, Heath, A C, Hek, K, Hofman, A, Homuth, G, Horn, C, Jan Hottenga, J, Kardia, S L R, Kloiber, S, Koenen, K, Kutalik, Z, Ladwig, K-H, Lahti, J, Levinson, D F, Lewis, C M, Lewis, G, Li, Q S, Llewellyn, D J, Lucae, S, Lunetta, K L, MacIntyre, D J, Madden, P, Martin, N G, McIntosh, A M, Metspalu, A, Milaneschi, Y, Montgomery, G W, Mors, O, Mosley, T H, Murabito, J M, Müller-Myhsok, B, Nöthen, M M, Nyholt, D R, O'Donovan, M C, Penninx, B W, Pergadia, M L, Perlis, R, Potash, J B, Preisig, M, Purcell, S M, Quiroz, J A, Räikkönen, K, Rice, J P, Rietschel, M, Rivera, M, Schulze, T G, Shi, J, Shyn, S, Sinnamon, G C, Smit, J H, Smoller, J W, Snieder, H, Tanaka, T, Tansey, K E, Teumer, A, Uher, R, Umbricht, D, Van der Auwera, S, Ware, E B, Weir, D R, Weissman, M M, Willemsen, G, Yang, J, Zhao, W, Tiemeier, H & Sullivan, P F 2017, ' An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype ', Biological Psychiatry, vol. 82, no. 5, pp. 322-329 . https://doi.org/10.1016/j.biopsych.2016.11.013
Direk, N, Williams, S, Smith, J A, Ripke, S, Air, T, Amare, A T, Amin, N, Baune, B T, Bennett, D A, Blackwood, D H R, Boomsma, D, Breen, G, Buttenschøn, H N, Byrne, E M, Børglum, A D, Castelao, E, Cichon, S, Clarke, T K, Cornelis, M C, Dannlowski, U, De Jager, P L, Demirkan, A, Domenici, E, van Duijn, C M, Dunn, E C, Eriksson, J G, Esko, T, Faul, J D, Ferrucci, L, Fornage, M, de Geus, E, Gill, M, Gordon, S D, Grabe, H J, van Grootheest, G, Hamilton, S P, Hartman, C A, Heath, A C, Hek, K, Hofman, A, Homuth, G, Horn, C, Jan Hottenga, J, Kardia, S L R, Kloiber, S, Koenen, K, Kutalik, Z, Ladwig, K H, Lahti, J, Levinson, D F, Lewis, C M, Lewis, G, Li, Q S, Llewellyn, D J, Lucae, S, Lunetta, K L, MacIntyre, D J, Madden, P, Martin, N G, McIntosh, A M, Metspalu, A, Milaneschi, Y, Montgomery, G W, Mors, O, Mosley, T H, Murabito, J M, Müller-Myhsok, B, Nöthen, M M, Nyholt, D R, O'Donovan, M C, Penninx, B W, Pergadia, M L, Perlis, R, Potash, J B, Preisig, M, Purcell, S M, Quiroz, J A, Räikkönen, K, Rice, J P, Rietschel, M, Rivera, M, Schulze, T G, Shi, J, Shyn, S, Sinnamon, G C, Smit, J H, Smoller, J W, Snieder, H, Tanaka, T, Tansey, K E, Teumer, A, Uher, R, Umbricht, D, Van der Auwera, S, Ware, E B, Weir, D R, Weissman, M M, Willemsen, G, Yang, J, Zhao, W, Tiemeier, H & Sullivan, P F 2017, ' An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype ', Biological Psychiatry, vol. 82, no. 5, pp. 322-329 . https://doi.org/10.1016/j.biopsych.2016.11.013
Direk, N, Williams, S, Smith, J A, Ripke, S, Air, T, Amare, A T, Amin, N, Baune, B T, Bennett, D A, Blackwood, D H R, Boomsma, D, Breen, G, Buttenschøn, H N, Byrne, E M, Børglum, A D, Castelao, E, Cichon, S, Clarke, T-K, Cornelis, M C, Dannlowski, U, De Jager, P L, Demirkan, A, Domenici, E, van Duijn, C M, Dunn, E C, Eriksson, J G, Esko, T, Faul, J D, Ferrucci, L, Fornage, M, Geus, E D, Gill, M, Gordon, S D, Grabe, H J, Grootheest, G V, Hamilton, S P, Hartman, C A, Heath, A C, Hek, K, Hofman, A, Homuth, G, Horn, C, Hottenga, J J, Kardia, S L R, Kloiber, S, Koenen, K, Kutalik, Z, Ladwig, K-H, Lahti, J, Levinson, D F, Lewis, C M, Lewis, G, Li, Q S, Llewellyn, D J, Lucae, S, Lunetta, K L, MacIntyre, D J, Madden, P, Martin, N G, McIntosh, A M, Metspalu, A, Milaneschi, Y, Montgomery, G W, Mors, O, Mosley Jr, T H, Murabito, J M, Müller-Myhsok, B, Nöthen, M M, Nyholt, D R, O’Donovan, M C, Penninx, B W, Pergadia, M L, Perlis, R, Potash, J B, Preisig, M, Purcell, S M, Quiroz, J A, Räikkönen, K, Rice, J P, Rietschel, M, Rivera Sanchez, M, Schulze, T G, Shi, J, Shyn, S, Sinnamon, G C, Smit, J H, Smoller, J W, Snieder, H, Tanaka, T, Tansey, K E, Teumer, A, Uher, R, Umbricht, D, der Auwera, S V, Ware, E B, Weir, D R, Weissman, M M, Willemsen, G, Yang, J, Zhao, W, Tiemeier, H & Sullivan, P F 2016, ' An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype ', Biological psychiatry . https://doi.org/10.1016/j.biopsych.2016.11.013
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2016.11.013
Popis: BACKGROUND: The genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder.METHODS: We analyzed two prior studies of 70,017 participants of European ancestry from general and clinical populations in the discovery stage. We performed a replication meta-analysis of 28,328 participants. Single nucleotide polymorphism (SNP)-based heritability and genetic correlations were calculated using linkage disequilibrium score regression. Discovery and replication analyses were performed using a p-value-based meta-analysis. Lifetime major depressive disorder and depressive symptom scores were used as the outcome measures.RESULTS: The SNP-based heritability of major depressive disorder was 0.21 (SE = 0.02), the SNP-based heritability of depressive symptoms was 0.04 (SE = 0.01), and their genetic correlation was 1.001 (SE = 0.2). We found one genome-wide significant locus related to the broad depression phenotype (rs9825823, chromosome 3: 61,082,153, p = 8.2 × 10(-9)) located in an intron of the FHIT gene. We replicated this SNP in independent samples (p = .02) and the overall meta-analysis of the discovery and replication cohorts (1.0 × 10(-9)).CONCLUSIONS: This large study identified a new locus for depression. Our results support a continuum between depressive symptoms and major depressive disorder. A phenotypically more inclusive approach may help to achieve the large sample sizes needed to detect susceptibility loci for depression.
Databáze: OpenAIRE
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