Changes in fatty acid levels after consumption of a novel docosahexaenoic supplement from algae: a crossover randomized controlled trial in omnivorous, lacto-ovo vegetarians and vegans

Autor: Elena García-Maldonado, Alexandra Alcorta, Belén Zapatera, M. Pilar Vaquero
Přispěvatelé: Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Comunidad de Madrid, Laboratorios Zamdeh
Rok vydání: 2022
Předmět:
Zdroj: European journal of nutrition.
ISSN: 1436-6215
Popis: [Purpose]: To determine serum fatty acids of lacto-ovo vegetarian (LOV), vegan (VEG) and omnivorous (OMN) adults, and to analyse the effects of consuming a docosahexaenoic acid (DHA) supplement of vegetable origin on fatty acid profile.
[Methods]: A randomized, double-blind, placebo-controlled crossover design was conducted in healthy adults. Volunteers (n = 116) were randomly assigned to a DHA-supplement (dose 250 mg/day), made from the microalgae Schizochytrium sp., or a placebo during 5-week periods separated by a 5-week washout interim period. Compliance and dietary intake were estimated and serum fatty acids were determined by gas chromatography. Results were analysed by mixed linear models.
[Results]: Percentage of linoleic acid (C18:2n6) in serum was the highest among the fatty acids in the three diet groups, followed by oleic (C18:1n9) and palmitic (C16:0) acids. Linoleic (C18:2n6) and alpha-linolenic (C18:3n3) acids were higher in VEG compared to OMN (p
[Conclusion]: The DHA-supplement at dose of 250 mg/day was effective in increasing serum DHA either in omnivorous, lacto-ovo vegetarian and vegan adults.
[Clinical trial registration]: Registered at Clinicaltrials.gov (www.clinicaltrials.gov), NCT04278482.
Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.
This study was funded by a Development of Industrial Doctorate project from the Community of Madrid, CSIC and Zamdeh Laboratories (IND2018/BIO-9554). E.G.-M. was the recipient of the industrial doctorate.
Databáze: OpenAIRE
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