C3d deposition in the media of renal arterioles is a useful marker for arteriolosclerosis in IgA nephropathy
| Autor: | Li-juan Qu, Rui Zhang, Zhiyong Zheng, Feng Zheng, Jian-song Lin |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Arteriolosclerosis chemical and pharmacologic phenomena Kaplan-Meier Estimate Kidney urologic and male genital diseases Peritubular capillaries Pathology and Forensic Medicine Nephropathy Young Adult Predictive Value of Tests medicine Humans In patient Retrospective Studies medicine.diagnostic_test business.industry Glomerulonephritis IGA Glomerulonephritis General Medicine Middle Aged Prognosis medicine.disease Kidney Transplantation Capillaries Transplantation Arterioles medicine.anatomical_structure Complement C3d Female Renal biopsy Tunica Media business Deposition (chemistry) Biomarkers Follow-Up Studies |
| Zdroj: | Annals of Diagnostic Pathology. 18:104-108 |
| ISSN: | 1092-9134 |
| DOI: | 10.1016/j.anndiagpath.2014.01.001 |
| Popis: | C3d deposition in peritubular capillaries has been demonstrated to indicate antibody-mediated alloresponse during renal transplantation. C3d deposition in renal arterioles in IgA nephropathy (IgAN), however, is poorly documented. Especially, its significance to the pathology of primary glomerulonephritis remains unclear. This retrospective study included 340 patients with IgAN who underwent renal biopsy at our center. C3d strongly positive deposition in arterioles was observed in 123 (36.2%) of the 340 cases, and weakly positive deposition of C3d was observed in 217 cases (63.8%). In the weakly positive group, C3d mainly deposited in the intima of arterioles. In the strongly positive group, C3d deposited in the intima and the media of arterioles, presenting as the medial thickening and sclerosis of varying severities. The prognosis was worse in the C3d strongly positive group than in the weakly positive group during a 2-year follow-up (P = .027). The predictive value of C3d deposition in the media of arterioles in patients with IgAN may be a useful marker for arteriolosclerosis indicating unfavorable clinical outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect