CD4 expression in neurons of the central nervous system
| Autor: | Marie-Chantal Marty, B Pessac, F Alliot, J Rutin, Alain Privat, C Levallois, B Omri, P Crisanti |
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| Rok vydání: | 1994 |
| Předmět: |
Nervous system
Ependymal Cell Immunoblotting Molecular Sequence Data Immunology Central nervous system Biology Polymerase Chain Reaction Mice medicine Animals Humans Immunology and Allergy RNA Messenger Microscopy Immunoelectron Cells Cultured In Situ Hybridization Neurons Base Sequence Brain General Medicine Immunohistochemistry Neuroregeneration Cell biology Blotting Southern medicine.anatomical_structure CD4 Antigens biology.protein Choroid plexus Neuron Neuroanatomy Neurotrophin |
| Zdroj: | International Immunology. 6:377-385 |
| ISSN: | 1460-2377 0953-8178 |
| DOI: | 10.1093/intimm/6.3.377 |
| Popis: | CD4 is a member of the Ig gene super family expressed on the surface of many thymocytes and of a subset of T lymphocytes. Human CD4 is the receptor for HIV envelope glycoprotein gp120. Human and mouse CD4 transcripts are expressed in human and mouse central nervous system (CNS), but no corresponding proteins have been reported yet. We have analyzed mRNA expression and carried out immunological experiments on adult mouse brain with probes specific for the long and short CD4 transcripts and with antibodies monospecific for mouse CD4. The main result of these experiments is that the full length CD4 transcript and the CD4 protein are expressed coordinately in neurons throughout the adult mouse brain. CD4 immunoreactivity is also present in brain small vessel walls, ependymal cells, and choroid plexus. The brain mouse CD4 protein is indistinguishable from the thymus protein. In addition, we show that neuronal cells in primary cultures from human fetal CNS are immunoreactive to human CD4 mAbs. |
| Databáze: | OpenAIRE |
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