Impact of Dengue Virus Serotype 2 Strain Diversity on Serological Immune Responses to Dengue
| Autor: | Bryan M. Zhao, Sarah L. Keasey, Stefan Fernandez, Robert G. Ulrich, Anna P. Durbin, Jessica L. Smith |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Serotype Adolescent viruses 030106 microbiology Disease Dengue virus Antibodies Viral Serogroup medicine.disease_cause Serology Dengue fever Dengue Young Adult 03 medical and health sciences Immune system Viral Envelope Proteins medicine Animals Humans Phylogeny Dengue vaccine biology Viral Vaccines Dengue Virus Middle Aged medicine.disease Antibodies Neutralizing Macaca mulatta Virology 030104 developmental biology Infectious Diseases biology.protein Female Antibody |
| Zdroj: | ACS Infectious Diseases. 4:1705-1717 |
| ISSN: | 2373-8227 |
| DOI: | 10.1021/acsinfecdis.8b00185 |
| Popis: | Dengue is a mosquito-borne disease caused by four dengue virus serotypes (DENV1-4) that are loosely categorized by sequence commonalities and antibody recognition profiles. The highly variable envelope protein (E) that is prominently displayed on the surface of DENV is an essential component of vaccines currently under development, yet the impact of using single strains to represent each serotype in tetravalent vaccines has not been adequately studied. We synthesized chimeric E by replacing highly variable residues from a dengue virus serotype 2 vaccine strain (PUO-218) with those from 16 DENV2 lineages spanning 60 years of antigen evolution. Examining sera from human and rhesus macaques challenged with single strains of DENV2, antibody-E interactions were markedly inhibited or enhanced by residues mainly focused within a 480 Å |
| Databáze: | OpenAIRE |
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