Concentrated autologous bone marrow aspirate transplantation versus conservative treatment for corticosteroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus
| Autor: | Yohei Tomaru, Kento Nawata, Hisashi Sugaya, Tomokazu Yoshioka, Masashi Yamazaki, Junichi Nanakamura, Seiji Ohtori, Hajime Mishima, Shigeo Hagiwara |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
030222 orthopedics
medicine.medical_specialty joint-preserving surgery medicine.drug_class business.industry concentrated autologous bone marrow aspirate transplantation Autologous bone Surgery Transplantation Conservative treatment 03 medical and health sciences Femoral head 0302 clinical medicine medicine.anatomical_structure Osteonecrosis of the femoral head Etiology medicine matching adjusted comparison Corticosteroid Original Article 030212 general & internal medicine Bone marrow Stage (cooking) business |
| Zdroj: | Journal of Rural Medicine : JRM |
| ISSN: | 1880-4888 1880-487X |
| Popis: | Objective: To compare the outcomes of steroid-associated osteonecrosis of the femoral head in patients with systemic lupus erythematosus who underwent conservative treatment and concentrated autologous bone marrow aspirate transplantation Methods: Osteonecrosis of the femoral head was classified according to the Japanese Investigation Committee system. Concentrated autologous bone marrow aspirate transplantation was performed by aspirating the bone marrow from both iliac crests and then transplanting it to the necrotic area after the core decompression. Patients with >2-year follow-up after the concentrated autologous bone marrow aspirate transplantation in our institution (Group I) and those with >2-year follow-up after the first hospital visit in a cooperative institution (Group II) were included in this study. After a randomized matching based on age, sex, type, stage, and etiology, the collapse rate in pre-collapsed stages and total hip arthroplasty conversion rate in all stages were compared between the two groups. Results: After the matching adjustment, 33 pairs of hips were included. Preoperatively, 1, 2, 16, and 14 hips were classified as types A, B, C1, and C2, respectively, and 15, 13, 2, and 3 hips were classified as stages 1, 2, 3A, and 3B, respectively. The collapse rates in the pre-collapsed stages were 68% and 39% in Groups I and II, respectively. Total hip arthroplasty conversion rates were 33% and 45% in Groups I and II, respectively. However, Group I had significantly higher and lower conversion rates in stages 1 and 3, respectively (both P |
| Databáze: | OpenAIRE |
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