The therapy of gefitinib towards breast cancer partially through reversing breast cancer biomarker arginine
| Autor: | Dongmei Geng, Dengjun Sun, Liangming Zhang, Weiwei Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Arginine Antineoplastic Agents Breast Neoplasms Sensitivity and Specificity Mass Spectrometry Pathogenesis Gefitinib Breast cancer Predictive Value of Tests Internal medicine medicine Humans Metabolomics skin and connective tissue diseases business.industry Case-control study Area under the curve General Medicine Articles medicine.disease Breast cancer arginine metabolomics gefitinib ROC Curve Predictive value of tests Area Under Curve Case-Control Studies Quinazolines Female business medicine.drug Targeted metabolomics |
| Zdroj: | African Health Sciences; Vol 15, No 2 (2015); 594-597 |
| ISSN: | 1680-6905 |
| Popis: | Background : Breast cancer remains the leading reason of cancer death among women worldwide, and gefitinib is the efficient drug for breast cancer. Aims : To use targeted metabolomics method to elucidate the therapeutic mechanism of gefitinib through profiling the amino acids. Methods : Healthy women (n=56) and women with breast cancer (n=60) were enrolled in Affiliated Yuhuangding hospital, medical college of Qingdao University from 2012-2014. API 3200 triple quadrupole mass spectrometer was used to analyze the serum samples. Results : The concentration of amino acids was compared between healthy women and women with breast cancers. Compared with the healthy women, the concentration of arginine in breast cancer women significantly decreased (p |
| Databáze: | OpenAIRE |
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