Disseminated necrotizing leukoencephalopathy following chemoradiation therapy for acute lymphoblastic leukemia
| Autor: | Kumiko Ando, Reiichi Ishikura, Yumi Kaneda, Norihiko Kamikonya, Ajaya R. Pande, Yuki Nagami, Masayo Ogawa, Takakuni Tanizawa, Norio Nakao |
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| Rok vydání: | 2006 |
| Předmět: |
Antimetabolites
Antineoplastic medicine.medical_specialty Pathology Lymphoblastic Leukemia medicine.medical_treatment Leukoencephalopathy Necrosis medicine Humans Radiology Nuclear Medicine and imaging Brain Diseases Radiation Cranial radiotherapy business.industry Brain Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Combined Modality Therapy Magnetic Resonance Imaging Hyperintensity Radiation therapy Methotrexate Oncology Child Preschool Female Radiology Cranial Irradiation Tomography X-Ray Computed business Complication Craniospinal medicine.drug |
| Zdroj: | Radiation Medicine. 24:515-519 |
| ISSN: | 1862-5274 0288-2043 |
| Popis: | Disseminated necrotizing leukoencephalopathy (DNL) is a potentially fatal complication of treatment involving intrathecal administration of chemotherapeutic agents such as methotrexate (MTX) alone or in combination with cranial radiotherapy (RT). We describe a case of acute lymphoblastic leukemia (ALL) treated with high-dose intravenous and intrathecal methotrexate combined with craniospinal RT resulting in DNL. Typical MR imaging features of progressive deep white matter lesions showing a characteristic pattern of enhancement after contrast was seen in this case. Deep white matter lesions with ring-like enhancement and calcifications were seen on CT; it showed a mass effect at one stage, which is not typical for DNL. Long-term clinical and imaging follow-up were helpful for the diagnosis in this case. |
| Databáze: | OpenAIRE |
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