Increased postoperative concentrations of tenascin-C in wound fluid
| Autor: | Kari Haukipuro, Päivi E. Mertaniemi, Heikki Wiik, Riitta Kaarteenaho-Wiik, Hannu Syrjälä, Juha Risteli |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Resuscitation medicine.medical_specialty Pathology Gastrointestinal Diseases Tenascin Inflammation Critical Care and Intensive Care Medicine Extracellular matrix Internal medicine medicine Humans Surgical Wound Infection chemistry.chemical_classification Wound Healing integumentary system biology business.industry Tenascin C Middle Aged Peptide Fragments Procollagen peptidase Endocrinology chemistry biology.protein Surgery Female medicine.symptom Wound healing Glycoprotein business Procollagen |
| Zdroj: | The Journal of trauma. 56(4) |
| ISSN: | 0022-5282 |
| Popis: | Background Tenascin-C (Tn-C) is the most studied member of a family comprising large oligomeric glycoproteins in the extracellular matrix. The function of Tn-C still is unclear, and the levels of Tn-C in human wound fluid have not been studied. Methods The participants in this study were 24 patients referred for elective major gastrointestinal surgery. Concentrations of Tn-C and procollagen propeptides type 1 and type 3 in serum and wound fluid were measured after surgery. Results In wound fluid, Tn-C was present on postoperative day 1, and the concentration increased from day 5 up to day 7. Conclusions The concentration of Tn-C increases postoperatively in wound fluid. The concentration of Tn-C in wound fluid is markedly higher than that of serum. The differences in expression between Tn-C and the procollagen propeptides may reflect different tasks of these extracellular matrix proteins. |
| Databáze: | OpenAIRE |
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