Adherence to a Mediterranean diet, dyslipidemia and inflammation in familial hypercholesterolemia

Autor: José Eduardo Krieger, Mauricio Teruo Tada, Alexandre C. Pereira, Raquel Arroyo-Olivares, Ovidio Muñiz-Grijalvo, Luiza Antoniazzi, Márcio Sommer Bittencourt, Pedro Mata, José Luis Díaz-Díaz, Cinthia E. Jannes, Isabella Ramos Lima, Gracia M. Quintana-Navarro, Rodrigo Alonso, Raul D. Santos
Rok vydání: 2021
Předmět:
Male
Time Factors
Apolipoprotein B
Mediterranean diet
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Familial hypercholesterolemia
030204 cardiovascular system & hematology
Diet
Mediterranean
Gastroenterology
chemistry.chemical_compound
0302 clinical medicine
Nutrition and Dietetics
biology
Middle Aged
Lipids
Treatment Outcome
Cardiovascular Diseases
Female
Diet
Healthy
Inflammation Mediators
medicine.symptom
Cardiology and Cardiovascular Medicine
Nutritive Value
Brazil
Adult
medicine.medical_specialty
030209 endocrinology & metabolism
Inflammation
Risk Assessment
Hyperlipoproteinemia Type II
03 medical and health sciences
Internal medicine
medicine
Humans
Cholesterol
business.industry
Mean age
Feeding Behavior
Protective Factors
medicine.disease
Cross-Sectional Studies
chemistry
Heart Disease Risk Factors
Spain
biology.protein
Patient Compliance
business
Risk Reduction Behavior
Biomarkers
Dyslipidemia
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 31:2014-2022
ISSN: 0939-4753
Popis: Familial Hypercholesterolemia (FH) is characterized by elevated LDL-cholesterol (LDL-C) and high atherosclerosis risk. The impact of different dietary patterns on atherosclerosis biomarkers has been poorly studied in FH. This study verified the association of adherence to a Mediterranean diet with biomarkers of dyslipidemia and low-grade inflammation in molecularly proven FH adults from Brazil (BR) and Spain (SP).In this cross-sectional study adherence to the Mediterranean diet was assessed by a validated score and generalized estimating equations were used to evaluate its association with plasma LDL-C, apolipoprotein-B (ApoB) and high sensitivity C-reactive protein (hs-CRP) concentrations. We included 92 (mean age 45 years, 58.7% females) and 98 FH individuals (mean age 46.8 years, 60.2% females) respectively from BR and SP. FH causing variants did not differ between countries. LDL-C, ApoB and hs-CRP concentrations were higher in BR than in SP: 179 (135-250) and 161 (133-193) mg/dL; 141 (109-181) and 103 (88-134) mg/dL; and 1.6 (0.8-4.0) and 0.8 (0.4-1.5) mg/L respectively (all p 0.001). Most of BR had low adherence (n = 77, 83.7%), while the majority of SP were divided into moderate (n = 35, 35.7%) and strong adherence to the Mediterranean diet (n = 37, 37.8%), p 0.001. There was a significant inverse association of adherence to the Mediterranean diet score with higher LDL-C, ApoB, and hs-CRP after adjusting for socio economic parameters, caloric and fatty acid intakes as well as pharmacological lipid lowering therapies.Higher adherence to a Mediterranean diet was associated with better dyslipidemia and low-grade inflammation profiles in FH.
Databáze: OpenAIRE
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