Disorganized Sensorimotor Integration in Mutation-Positive Myoclonus-Dystonia A Functional Magnetic Resonance Imaging Study
| Autor: | Michiel B. de Ruiter, Elisabeth M. J. Foncke, Johan N. van der Meer, Richard J. Beukers, Marina A. J. Tijssen, Dick J. Veltman, Lo J. Bour, Aart J. Nederveen |
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| Přispěvatelé: | Neuroscience Campus Amsterdam - Neurodegeneration, Neuroscience Campus Amsterdam - Brain Imaging, Amsterdam Neuroscience, Neurology, Amsterdam Cardiovascular Sciences, Radiology and Nuclear Medicine, Adult Psychiatry, Other departments, Psychiatry, NCA - Brain Imaging, NCA - Neurodegeneration |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Myoclonus Movement disorders Torsion dystonia AREAS Cerebellum Parietal Lobe Task Performance and Analysis RATING-SCALE Dystonia Brain Mapping medicine.diagnostic_test Motor Cortex Brain Middle Aged Magnetic Resonance Imaging FOCAL HAND DYSTONIA TORSION DYSTONIA Dystonic Disorders Cerebrovascular Circulation Female medicine.symptom Psychology MOTOR RECEPTOR-BINDING Adult Heterozygote Genotype MOVEMENT Young Adult Arts and Humanities (miscellaneous) SGCE Sarcoglycans medicine Humans Genetic Predisposition to Disease EPSILON-SARCOGLYCAN Aged Magnetic resonance imaging WRITERS CRAMP Somatosensory Cortex medicine.disease Functional imaging Case-Control Studies Mutation Neurology (clinical) ACTIVATION PATTERNS Nerve Net Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Archives of Neurology, 67(4), 469-474. American Medical Association Archives of Neurology, 67(4), 469-474. AMER MEDICAL ASSOC Archives of neurology, 67(4), 469-474. American Medical Association Beukers, R J, Foncke, E M J, van der Meer, J N, Nederveen, A J, de Ruiter, M B, Bour, L J, Veltman, D J & Tijssen, M A J 2010, ' Disorganized Sensorimotor Integration in Mutation-Positive Myoclonus-Dystonia A Functional Magnetic Resonance Imaging Study ', Archives of Neurology, vol. 67, no. 4, pp. 469-474 . https://doi.org/10.1001/archneurol.2010.54 |
| ISSN: | 0003-9942 |
| DOI: | 10.1001/archneurol.2010.54 |
| Popis: | Background: Myoclonus-dystonia is an autosomal dominantly inherited movement disorder clinically characterized by myoclonic jerks and dystonic postures or movements of the upper body. Functional imaging studies in other, mainly heterogeneous groups of dystonia do agree on dysfunction of the striato-pallido-thalamo-cortical circuit.Objective: To study cerebral activation patterns with functional magnetic resonance imaging in a genetically defined homogeneous group of patients with dystonia.Design, Setting, and Patients: Thirteen clinically affected SGCE mutation carriers and 11 control subjects were studied in a case-control study.Intervention: A finger-tapping motor task was performed in a block design using 3.0-T magnetic resonance imaging.Main Outcome Measures: Blood oxygenation level-dependent signals were compared between groups.Results: In SGCE mutation carriers, we observed significant hyperresponsiveness in contralateral inferior parietal cortical areas, ipsilateral premotor and primary somatosensory cortex, and ipsilateral cerebellum during the motor task compared with healthy control subjects.Conclusions: The cortical activation patterns in SGCE mutation carriers during this motor task point to a disorganized sensorimotor integration in this uniform group of patients with dystonia and are consistent with functional neuroimaging studies in other types of (hereditary) dystonia. |
| Databáze: | OpenAIRE |
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