Hypovitaminosis D and prevalent asymptomatic vertebral fractures in Moroccan postmenopausal women
| Autor: | Saida Tellal, Abdellah El Maghraoui, Mohamed Dehhaoui, Imad Ghozlani, Zhor Ouzzif, Ahmed Bezza, Aziza Mounach, Lahsen Achemlal, Asmaa Rezqi |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Bone density Osteoporosis 25(OH) vitamin D VFA lcsh:Gynecology and obstetrics Gastroenterology Asymptomatic vitamin D deficiency Cohort Studies Bone Density Risk Factors Internal medicine Obstetrics and Gynaecology Prevalence medicine Vitamin D and neurology Humans Vitamin D lcsh:RG1-991 Aged DXA Gynecology Bone mineral Medicine(all) business.industry lcsh:Public aspects of medicine Age Factors Obstetrics and Gynecology lcsh:RA1-1270 General Medicine Middle Aged Vitamin D Deficiency medicine.disease Postmenopause Morocco Cross-Sectional Studies Reproductive Medicine Vertebral fractures Cohort Spinal Fractures Women's Health Female medicine.symptom business Research Article Cohort study |
| Zdroj: | BMC Women's Health, Vol 12, Iss 1, p 11 (2012) BMC Women's Health |
| ISSN: | 1472-6874 |
| DOI: | 10.1186/1472-6874-12-11 |
| Popis: | Background Hypovitaminosis D is associated to accentuated bone loss. However, association between osteoporotic vertebral fractures (VFs) and vitamin D status has not been clearly established. Objective To determine serum vitamin D status and to assess the association of vitamin D status with bone mineral density (BMD) and asymptomatic VFs prevalence using vertebral fracture assessment (VFA) in a cohort of Moroccan menopausal women. Methods from June to September 2010, 178 menopausal women 50 years old and over were enrolled in this cross-sectional study. The mean ± SD (range) age, weight, height and BMI were 58.8 ± 8.2 (50 to 79) years, 73.2 ± 13.8 (35 to 119) Kgs, 1.56 ± 0.06 (1.43 – 1.79) m and 29.8 ± 5.9 (17.5 – 49.8) kg/m2, respectively. VFA images and scans of the lumbar spine and proximal femur were obtained using a GE Healthcare Lunar Prodigy densitometer. VFs were defined using a combination of Genant semiquantitative approach and morphometry. Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured. Results Among the 178 women, 45 (25.2%) had densitometric osteoporosis, and on VFA, VFs (grade 2 or 3) were detected in 20.2% while grade 1 were identified in 33.1%. The mean values of serum levels of 25(OH)D were 15.8 ± 11.6 ng/ml (range: 3.0 – 49.1) with 152 patients (85.3%) having levels Conclusion our study shows that advanced age, hypovitaminosis D and osteoporosis are independent risk factors for asymptomatic VFs in Moroccan postmenopausal women. |
| Databáze: | OpenAIRE |
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