Stimuli-Responsive Polymers for Transdermal, Transmucosal and Ocular Drug Delivery
| Autor: | Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Temirkhanova, Arman Saparov, Kamila Raziyeva, Dmitriy Berillo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
stimuli-responsive polymers Primary metabolism Stimuli responsive business.industry media_common.quotation_subject oromucosal drug delivery mucoadhesive properties Pharmaceutical Science Review Absorption (skin) Pharmacology Controlled release transdermal drug delivery ocular drug delivery Bioavailability nasal drug delivery RS1-441 Pharmacy and materia medica Drug delivery Medicine business media_common Transdermal |
| Zdroj: | Pharmaceutics, Vol 13, Iss 2050, p 2050 (2021) Pharmaceutics |
| ISSN: | 1999-4923 |
| Popis: | Despite their conventional and widespread use, oral and intravenous routes of drug administration face several limitations. In particular, orally administered drugs undergo enzymatic degradation in the gastrointestinal tract and first-pass metabolism in the liver, which tend to decrease their bioavailability. Intravenous infusions of medications are invasive, painful and stressful for patients and carry the risk of infections, tissue damage and other adverse reactions. In order to account for these disadvantages, alternative routes of drug delivery, such as transdermal, nasal, oromucosal, ocular and others, have been considered. Moreover, drug formulations have been modified in order to improve their storage stability, solubility, absorption and safety. Recently, stimuli-responsive polymers have been shown to achieve controlled release and enhance the bioavailability of multiple drugs. In this review, we discuss the most up-to-date use of stimuli-responsive materials in order to optimize the delivery of medications that are unstable to pH or undergo primary metabolism via transdermal, nasal, oromucosal and ocular routes. Release kinetics, diffusion parameters and permeation rate of the drug via the mucosa or skin are discussed as well. |
| Databáze: | OpenAIRE |
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