Multiple cavities with halo sign in a case of invasive pulmonary aspergillosis during therapy for drug-induced hypersensitivity syndrome
| Autor: | Tomoo Ikari, Yasushi Akiyama, Toshiyuki Harada, Masashi Ohe, Katsura Nagai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Case Report Chronic obstructive pulmonary disease (COPD) Invasive pulmonary aspergillosis GGO ground grass opacity LAA low attenuation area Halo sign 03 medical and health sciences 0302 clinical medicine Drug-induced hypersensitivity syndrome IPA invasive pulmonary aspergillosis DIHS drug-induced hypersensitivity syndrome medicine Human herpes virus 6 (HHV-6) VRCZ voriconazole 030212 general & internal medicine skin and connective tissue diseases lcsh:RC705-779 DRESS drug reaction with eosinophilia and systemic syndrome COPD business.industry Clinical course HHV-6 Human herpes virus 6 Overlap syndrome lcsh:Diseases of the respiratory system CMV cytomegalovirus medicine.disease MCFG micafungin Dermatology BG 1 3-β-glucan Peripheral blood respiratory tract diseases CT computed tomography 030228 respiratory system COPD chronic obstructive pulmonary disease Rheumatoid arthritis BAL bronchoalveolar lavage medicine.symptom business GM galactomannan antigenemia |
| Zdroj: | Respiratory Medicine Case Reports Respiratory Medicine Case Reports, Vol 21, Iss C, Pp 124-128 (2017) |
| ISSN: | 2213-0071 |
| Popis: | A 67-year-old female with rheumatoid arthritis and asthma-chronic obstructive pulmonary disease overlap syndrome was admitted for drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine. Human herpes virus 6 (HHV-6) variant B was strongly positive on peripheral blood. Multiple cavities with ground grass opacities rapidly emerged predominantly in the upper and middle lobes. She was diagnosed with invasive pulmonary aspergillosis (IPA), and was treated successfully with antifungal agents. Therapeutic systemic corticosteroids, emphysematous change in the lungs, and the worsening of the patient's general condition due to DIHS were considered major contributing factor leading to IPA. HHV-6 reactivation could have an effect on clinical course of IPA. Cavities with halo sign would provide an early clue to IPA in non-neutropenic and immunosuppressive patients. |
| Databáze: | OpenAIRE |
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