NLR and Intestinal Dysbiosis-Associated Inflammatory Illness: Drivers or Dampers?
| Autor: | Rita C. Tostes, Ítalo Sousa Pereira, João Santana da Silva, Jefferson A. Leite, Daniela Carlos, Jefferson Elias-Oliveira, Gabriel Martins da Costa Manso, Jhefferson Barbosa Guimaraes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Mini Review Immunology inflammatory diseases Inflammation NLR Proteins Disease Gut flora 03 medical and health sciences 0302 clinical medicine gut dysbiosis medicine microbiota Immunology and Allergy Animals Humans Receptor NLRs Innate immune system biology diabetes Interleukin Inflammasome medicine.disease biology.organism_classification Ulcerative colitis Gastrointestinal Microbiome 030104 developmental biology Dysbiosis medicine.symptom lcsh:RC581-607 RECEPTORES IMUNOLÓGICOS 030215 immunology medicine.drug |
| Zdroj: | Frontiers in Immunology, Vol 11 (2020) Frontiers in Immunology Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2020.01810/full |
| Popis: | The intestinal microbiome maintains a close relationship with the host immunity. This connection fosters a health state by direct and indirect mechanisms. Direct influences occur mainly through the production of short-chain fatty acids (SCFAs), gastrointestinal hormones and precursors of bioactive molecules. Indirect mechanisms comprise the crosstalk between bacterial products and the host's innate immune system. Conversely, intestinal dysbiosis is a condition found in a large number of chronic intestinal inflammatory diseases, such as ulcerative colitis and Crohn's disease, as well as in diseases associated with low-grade inflammation, such as obesity, type 1 and 2 diabetes mellitus and cardiovascular diseases. NOD-Like receptors (NLRs) are cytoplasmic receptors expressed by adaptive and innate immune cells that form a multiprotein complex, termed the inflammasome, responsible for the release of mature interleukin (IL)-1β and IL-18. NLRs are also involved in the recognition of bacterial components and production of antimicrobial molecules that shape the gut microbiota and maintain the intestinal homeostasis. Recent novel findings show that NLRs may act as positive or negative regulators of inflammation by modulating NF-κB activation. This mini-review presents current and updated evidence on the interplay between NLRs and gut microbiota and their dual role, contributing to progression or conferring protection, in diabetes and other inflammatory diseases. |
| Databáze: | OpenAIRE |
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