Analysis of tau haplotypes in Pick's disease
| Autor: | H. Houlden, Andrew J. Lees, Patrick L. McGeer, Catherine Bergeron, JC Janssen, Murray Grossman, Matthew C. Baker, John Hardy, M. N. Khan, Huw R. Morris, T Revesz, Martin N. Rossor, Eileen H. Bigio, Nicholas W. Wood, Mike Hutton, John Q. Trojanowski, Peter L. Lantos, K. Yasojima |
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| Rok vydání: | 2002 |
| Předmět: |
Pathology
medicine.medical_specialty Genotype Tau protein tau Proteins Biology Progressive supranuclear palsy Degenerative disease Pick Disease of the Brain mental disorders medicine Humans Alleles Aged Chi-Square Distribution Haplotype Brain Middle Aged medicine.disease eye diseases Genotype frequency Haplotypes biology.protein Pick's disease Neurology (clinical) Tauopathy |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | Pick's disease (PiD) is characterized by the deposition of tau protein as three-repeat tau Pick bodies, whereas progressive supranuclear palsy (PSP) involves the deposition of four-repeat tau neurofibrillary tangles. PSP is associated with the tau H1 haplotype. The authors investigated a possible association between PiD and the tau H1 or H2 haplotype. There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects. No tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies. |
| Databáze: | OpenAIRE |
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