CHOROIDAL THICKNESS IN BEST VITELLIFORM MACULAR DYSTROPHY
| Autor: | Francesco Bandello, Claudia Del Turco, Riccardo Sacconi, Pierluigi Iacono, Maurizio Battaglia Parodi |
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| Přispěvatelé: | Parodi, Mb, Sacconi, R, Iacono, P, Del Turco, C, Bandello, Francesco |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Visual acuity Adolescent Visual Acuity Vitelliform macular dystrophy 03 medical and health sciences Young Adult 0302 clinical medicine Ophthalmology medicine Humans Prospective Studies Stage (cooking) Prospective cohort study Child Aged Aged 80 and over business.industry Choroid Significant difference Healthy subjects General Medicine Organ Size Middle Aged medicine.disease eye diseases Vitelliform Macular Dystrophy Best Vitelliform Macular Dystrophy 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry Female sense organs medicine.symptom business Tomography Optical Coherence |
| Zdroj: | Retina (Philadelphia, Pa.). 36(4) |
| ISSN: | 1539-2864 |
| Popis: | PURPOSE To assess the changes in choroidal thickness in different stages of Best vitelliform macular dystrophy (VMD). METHODS Thirty-four patients affected by VMD were prospectively enrolled and underwent a complete ophthalmologic examination, including best-corrected visual acuity measurement, biomicroscopic examination, and spectral domain optical coherence tomography. The Gass classification was used in defining the stages of VMD. Twenty healthy subjects served as the control group. Main outcome measures were the identification of choroidal changes in different stages of VMD and detection of a correlation between choroidal thickness and best-corrected visual acuity. RESULTS No significant difference was found in the subfoveal choroidal thickness (SFCT) between eyes displaying Stage 1 and the control group (P = 0.181). Stages 2 and 3 showed an increased SFCT (320.4 and 319.1 μm, respectively) compared with that of control patients (P < 0.001 and P = 0.004, respectively). Stage 4 had a significantly inferior SFCT compared with Stages 2 and 3 (P = 0.007 and P = 0.025, respectively) but no significant difference was found between Stage 4 and control patients (P = 0.733). The Stage 5 group displayed a significant decrease in SFCT compared with that of the control group (181.3 μm and 238.4 μm, respectively, P = 0.002). Analyzing the association between SFCT and best-corrected visual acuity in patients affected by clinical VMD (Stages 2-5), the authors found that the best-corrected visual acuity decreased as the choroid thinned (P = 0.004). CONCLUSION Choroidal thickness varies according to the stage of VMD, being higher in the vitelliform stage and thinner in the atrophic/cicatricial stage. Long-term studies are warranted to provide a more precise evaluation of the morphofunctional alterations in the different stages of VMD. |
| Databáze: | OpenAIRE |
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