Fibronectin-guided migration of carcinoma collectives

Autor: Shelia M. Violette, Paul H. Weinreb, Stéphanie Beghelli-de la Forest Divonne, Marius Ilie, Stéphane Audebert, Agata Radwanska, Dominique Grall, Emilie Baudelet, Anne Sudaka, Catherine Butori, Samah Rekima, Sandeep Gopal, Ellen Van Obberghen-Schilling, Luc Camoin, Sébastien Schaub, Laurence Veracini, Paul Hofman
Přispěvatelé: Audebert, Stéphane, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre de recherche en Biologie cellulaire de Montpellier (CRBM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de signalisation, biologie du développement et cancer (ISBDC), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Laboratoire de Pathologie Clinique et Expérimentale. Hôpital Pasteur [Nice], Hôpital Pasteur [Nice] (CHU), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Biogen [Cambridge, USA], Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Laboratory of Clinical and Experimental Pathology, Louis Pasteur Hospital, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Pathologie Clinique et Expérimentale, Centre Hospitalier Universitaire de Nice (CHU Nice), Human Biobank CHUN
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Adult
Male
Integrins
Science
Cell
Integrin
General Physics and Astronomy
[SDV.CAN]Life Sciences [q-bio]/Cancer
General Biochemistry
Genetics and Molecular Biology
Article
Extracellular matrix
03 medical and health sciences
Stroma
[SDV.CAN] Life Sciences [q-bio]/Cancer
Cell Movement
Cell Line
Tumor
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
Carcinoma
medicine
Humans
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
Fibroblast
[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
Aged
Aged
80 and over
Multidisciplinary
biology
Squamous Cell Carcinoma of Head and Neck
General Chemistry
Middle Aged
medicine.disease
Cell biology
Extracellular Matrix
Fibronectins
Fibronectin
Gene Expression Regulation
Neoplastic
030104 developmental biology
medicine.anatomical_structure
Cell culture
Head and Neck Neoplasms
biology.protein
Carcinoma
Squamous Cell
[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
Female
Zdroj: Nature Communications
Nature Communications, 2017, 8, pp.14105. ⟨10.1038/ncomms14105⟩
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Nature Publishing Group, 2017, 8, pp.14105. ⟨10.1038/ncomms14105⟩
ISSN: 2041-1723
Popis: Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell carcinomas (HNSCC). FN overexpression in tumours from 435 patients corresponds to an independent unfavourable prognostic indicator. We show that migration of carcinoma collectives on fibrillar FN-rich matrices is achieved through αvβ6 and α9β1 engagement, rather than α5β1. Moreover, αvβ6-driven migration occurs independently of latent TGF-β activation and Smad-dependent signalling in tumour epithelial cells. These results provide insights into the adhesion-dependent events at the tumour–stroma interface that govern the collective mode of migration adopted by carcinoma cells to invade surrounding stroma in HNSCC.
Tumour microenvironment influences the migration of cancer cells. Here the authors analyse the proteomic constitution of the extracellular matrix and identify a role for fibronectin in regulating the collective migration of squamous cell carcinoma cells.
Databáze: OpenAIRE
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