Role of glnA-linked genes in regulation of glutamine synthetase and histidase formation in Klebsiella aerogenes
| Autor: | Boris Magasanik, N Rothman, D Rothstein, F Foor |
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| Rok vydání: | 1982 |
| Předmět: |
Genetics
Transposable element Ammonia-Lyases Genetic Linkage Mutant Structural gene Chromosome Mapping Biology Enterobacter aerogenes biology.organism_classification Microbiology Klebsiella pneumoniae Genes Biochemistry Glutamate-Ammonia Ligase Glutamine synthetase Genes Regulator Mutation DNA Transposable Elements Histidine Ammonia-Lyase Molecular Biology Gene Histidine ammonia-lyase Research Article Regulator gene |
| Zdroj: | Journal of Bacteriology. 150:221-230 |
| ISSN: | 1098-5530 0021-9193 |
| Popis: | We isolated mutants of Klebsiella aerogenes with insertions of transposon Tn5 linked to the structural gene for glutamine synthetase, glnA. We found that K. aerogenes, like Escherichia coli and Salmonella typhimurium, contains a regulatory gene, glnG, which is closely linked to but distinct from glnA. The product of glnG is essential for normal regulation of the synthesis of glutamine synthetase and histidase. We analyzed two mutations which affected the regulation of the formation of these enzymes and appeared to be outside glnG. The results of our studies suggest the presence in K. aerogenes of at least two regulatory genes located in the glnA region, namely, glnG and another gene, the transcription of which can be initiated at the promoter of glnA. |
| Databáze: | OpenAIRE |
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