Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits
| Autor: | K Parton, Mark G. Collett, Zoe Maree Matthews |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
rabbits Health Toxicology and Mutagenesis Butanols Brassica lcsh:Medicine Physiology Pilot Projects Toxicology medicine.disease_cause 0403 veterinary science chemistry.chemical_compound Liver disease brassica-associated liver disease 0303 health sciences biology nitrile food and beverages 04 agricultural and veterinary sciences Liver Toxicity 1-cyano-2-hydroxy-3-butene Chemical and Drug Induced Liver Injury 040301 veterinary sciences Glucosinolates Alkenes Risk Assessment Article 1-cyano-2-hydroxy-3 4-epithiobutane 03 medical and health sciences Necrosis Massive Hepatic Necrosis Nitriles Toxicity Tests medicine Animals Goitrin 030304 developmental biology Progoitrin progoitrin Dose-Response Relationship Drug Toxin lcsh:R toxicity biology.organism_classification medicine.disease BALD chemistry Glucosinolate veterinary_medicine Biomarkers |
| Zdroj: | Toxins Toxins, Vol 12, Iss 695, p 695 (2020) Volume 12 Issue 11 |
| ISSN: | 2072-6651 |
| Popis: | Cattle occasionally develop brassica-associated liver disease (BALD) and photosensitisation when grazing turnip or swede (Brassica spp.) forage crops. The liver toxin in these brassica varieties has yet to be discovered. Progoitrin is the dominant glucosinolate in incriminated crops. Apart from goitrin, progoitrin hydrolysis yields the nitrile, 1-cyano-2-hydroxy-3-butene (CHB), and the epithionitrile, 1-cyano-2-hydroxy-3,4-epithiobutane (CHEB). The two compounds were custom-synthesised. In a small pilot trial, New Zealand White rabbits were given either CHB or CHEB by gavage. Single doses of 0.75 mmol/kg of CHB or 0.25 mmol/kg of CHEB were subtoxic and elicited subclinical effects. Higher doses were severely hepatotoxic, causing periportal to massive hepatic necrosis associated with markedly elevated serum liver biomarkers often resulting in severe illness or death within 24 h. The possibility that one or both of these hepatotoxic nitriles causes BALD in cattle requires further investigation. |
| Databáze: | OpenAIRE |
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