Lipid metabolism and Calcium signaling in epithelial ovarian cancer
| Autor: | Aurélie Chantôme, Marie Potier-Cartereau, Sana Kouba, Caroline Goupille, Christophe Vandier, Lobna Ouldamer, Céline Garcia, Delphine Fontaine |
|---|---|
| Přispěvatelé: | Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de gynécologie-obstétrique [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Gynécologie-Obstétrique [CHRU Tours], CCSD, Accord Elsevier |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
endocrine system diseases Physiology Carcinogenesis Disease medicine.disease_cause Pathogenesis chemistry.chemical_compound 0302 clinical medicine Lysophosphatidic acid Medicine MESH: Animals Calcium signaling MESH: Lipid Metabolism Ovarian Neoplasms Arachidonic Acid MESH: Risk MESH: Carcinogenesis female genital diseases and pregnancy complications 3. Good health MESH: Ovarian Neoplasms MESH: Epithelial Cells Female Risk MESH: Receptor Cross-Talk [SDV.CAN]Life Sciences [q-bio]/Cancer MESH: Calcium Signaling MESH: Lysophospholipids 03 medical and health sciences [SDV.CAN] Life Sciences [q-bio]/Cancer Animals Humans Calcium Signaling Molecular Biology MESH: Humans business.industry Lipid metabolism Epithelial Cells Cell Biology Lipid signaling Receptor Cross-Talk Lipid Metabolism MESH: Arachidonic Acid 030104 developmental biology chemistry Cancer cell Cancer research Lysophospholipids business MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Cell Calcium Cell Calcium, Elsevier, 2019, 81, pp.38-50. ⟨10.1016/j.ceca.2019.06.002⟩ Cell Calcium, 2019, 81, pp.38-50. ⟨10.1016/j.ceca.2019.06.002⟩ |
| ISSN: | 0143-4160 1532-1991 |
| Popis: | International audience; Epithelial Ovarian cancer (EOC) is the deadliest gynecologic malignancy and represents the fifth leading cause of all cancer-related deaths in women. The majority of patients are diagnosed at an advanced stage of the disease that has spread beyond the ovaries to the peritoneum or to distant organs (stage FIGO III-IV) with a 5-year overall survival of about 29%. Consequently, it is necessary to understand the pathogenesis of this disease. Among the factors that contribute to cancer development, lipids and ion channels have been described to be associated to cancerous diseases particularly in breast, colorectal and prostate cancers. Here, we reviewed the literature data to determine how lipids or lipid metabolites may influence EOC risk or progression. We also highlighted the role and the expression of the calcium (Ca2+) and calcium-activated potassium (KCa) channels in EOC and how lipids might regulate them. Although lipids and some subclasses of nutritional lipids may be associated to EOC risk, lipid metabolism of LPA (lysophosphatidic acid) and AA (arachidonic acid) emerges as an important signaling network in EOC. Clinical data showed that they are found at high concentrations in EOC patients and in vitro and in vivo studies referred to them as triggers of the Ca2+entry in the cancer cells inducing their proliferation, migration or drug resistance. The cross-talk between lipid mediators and Ca2+ and/or KCa channels needs to be elucidated in EOC in order to facilitate the understanding of its outcomes and potentially suggest novel therapeutic strategies including treatment and prevention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect