Effect of H-7 and Lat-B on Retinal Physiology

Autor:	Paul L. Kaufman, Jennifer A. Peterson, C. B. Y. Kim, T.M. Nork, Julie A. Kiland, B'Ann T. Gabelt, C.L. Miller, J.N. Ver Hoeve
Rok vydání:	2006
Předmět:	medicine.medical_specialty genetic structures Dark Adaptation Vascular permeability Biology Fluorophotometry Retina Injections Capillary Permeability Cellular and Molecular Neuroscience chemistry.chemical_compound 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Ophthalmology Electroretinography medicine Animals Scotopic vision Enzyme Inhibitors Fluorescein Angiography Fluorescein medicine.diagnostic_test Retinal Vessels Retinal Anatomy Intravitreal administration Bridged Bicyclo Compounds Heterocyclic Fluorescein angiography Macaca mulatta eye diseases Sensory Systems Vitreous Body Macaca fascicularis Thiazoles medicine.anatomical_structure chemistry Thiazolidines Marine Toxins sense organs Photic Stimulation Photopic vision
Zdroj:	Current Eye Research. 31:441-455
ISSN:	1460-2202 0271-3683
DOI:	10.1080/02713680600672185
Popis:	To investigate the effects of H-7 and Latrunculin B (Lat-B) on retinal vascular permeability and electrophysiology at concentrations that increase outflow facility in monkeys.One eye of 1 rhesus and 22 cynomolgus monkeys received an intravitreal bolus injection of H-7 or Lat-B; the opposite eye received vehicle. Multifocal electroretinograms (mfERGs), and photopic and scotopic full-field electroretinograms (ffERGs, sERGs) were recorded in subsets of monkeys at baseline and at multiple time-points post-H-7 or Lat-B. Vitreous fluorophotometry (VF) and fluorescein angiography (FA) were also performed.No differences between the H-7 or Lat-B treated and control eyes were found in ffERGs, mfERGs, sERGs, or in FAs in any monkey. No significant difference was found in vitreous fluorescein levels between H-7 treated or Lat-B treated vs. control eyes.No effect on retinal vascular permeability or retinal electrophysiology was apparent after intravitreal administration of H-7 or Lat-B at doses that increase outflow facility and lower IOP when given intracamerally.
Databáze:	OpenAIRE
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